Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 Biomarker LHGDN Positive correlation of osteopontin, cyclooxygenase-2 and vascular endothelial growth factor in gastric cancer. 18181047

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma. 18462890

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 18373164

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. 18775915

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 GeneticVariation LHGDN The COX-2 promoter polymorphism -765 G>C is associated with early-onset, conventional and stump gastric cancers. 18311113

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells. 17982644

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Celecoxib could reverse the hypoxia-induced Angiopoietin-2 upregulation in gastric cancer. 16338068

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 Biomarker LHGDN Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. 16474375

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Proapoptotic activity of NAG-1 is cell type specific and not related to COX-2 expression. 16699947

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. 16371352

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Increased expression of interleukin-1alpha and cyclooxygenase-2 in human gastric cancer: a possible role in tumor progression. 16101131

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 Biomarker LHGDN Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR. 16243808

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis. 16097070

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 PosttranslationalModification LHGDN Mechanism and clinical significance of cyclooxygenase-2 expression in gastric cancer. 15929174

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Expression of COX-2 proteins in gastric mucosal lesions. 14716842

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 PosttranslationalModification LHGDN Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma. 12684668

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 Biomarker LHGDN Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. 12767510

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN Association of cyclooxygenase-2 expression with Hp-cagA infection in gastric cancer. 12532440

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 AlteredExpression LHGDN [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior]. 12452062

2002