Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer. 18519679

2008

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab. 18625725

2008

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer. 18184439

2008

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53. 18317451

2008

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients. 18087195

2007

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation. 17935714

2007

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation. 17520698

2007

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN HER-2/neu transcriptionally activates Jab1 expression via the AKT/beta-catenin pathway in breast cancer cells. 17914096

2007

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN p38MAPK-activated AKT in HER-2 overexpressing human breast cancer cells acts as an EGF-independent survival signal. 17612563

2007

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. 17299206

2006

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. 16537497

2006

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN AKT regulation of estrogen receptor beta transcriptional activity in breast cancer. 16951146

2006

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Regulated association of protein kinase B/Akt with breast tumor kinase. 15539407

2005

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2. 15987444

2005

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. 15806160

2005

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN HER2/neu uses Akt to suppress retinoic acid response element binding activity in MDA-MB-453 breast cancer cells. 14612949

2003

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. 12244302

2002

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 PosttranslationalModification LHGDN Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. 12244303

2002