Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy. 18669459

2008

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients. 18698041

2008

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. 18216219

2008

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 GeneticVariation LHGDN Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer. 17904846

2008

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN A novel gene STYK1/NOK is upregulated in estrogen receptor-alpha negative estrogen receptor-beta positive breast cancer cells following estrogen treatment. 17415682

2008

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Evaluation of estrogen receptor alpha and beta and progesterone receptor expression and correlation with clinicopathologic factors and proliferative marker Ki-67 in breast cancers. 18234277

2008

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer. 17428314

2007

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Estrogen receptor-beta: why may it influence clinical outcome in estrogen receptor-alpha positive breast cancer? 17617929

2007

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN The effect of chemotherapy on status of estrogen receptors in primary tumors and lymph node metastases of human ductal breast cancer. 17203178

2007

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Association of oestrogen receptor beta 2 (ER beta 2/ER beta cx) with outcome of adjuvant endocrine treatment for primary breast cancer--a retrospective study. 17640362

2007

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN ERbeta shifts from mitochondria to nucleus during estrogen-induced neoplastic transformation of human breast epithelial cells and is involved in estrogen-induced synthesis of mitochondrial respiratory chain proteins. 17604135

2007

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Nuclear and cytoplasmic interaction of pRb2/p130 and ER-beta in MCF-7 breast cancer cells. 16760287

2006

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 GeneticVariation LHGDN Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease. 16808847

2006

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN AKT regulation of estrogen receptor beta transcriptional activity in breast cancer. 16951146

2006

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Combined profile of the tandem repeats CAG, TA and CA of the androgen and estrogen receptor genes in breast cancer. 16791593

2006

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer. 16261413

2005

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Phytoestrogens induce differential estrogen receptor alpha- or Beta-mediated responses in transfected breast cancer cells. 16118406

2005

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Estrogen receptor beta (ER beta) level but not its ER beta cx variant helps to predict tamoxifen resistance in breast cancer. 15355905

2004

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN Expression of estrogen receptors-alpha and -beta in primary breast neoplasms and tumors exposed to neoadjuvant hormonal therapy. 15723135

2004

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 PosttranslationalModification LHGDN CpG methylation of the ERalpha and ERbeta genes in breast cancer. 15254780

2004

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN ERbeta exerts multiple stimulative effects on human breast carcinoma cells. 15208676

2004

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer. 14715875

2004

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 GeneticVariation LHGDN The expression of ER beta cx in human breast cancer and the relationship to endocrine therapy and survival. 15073120

2004

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker LHGDN Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. 14745018

2004

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 AlteredExpression LHGDN ERbeta sensitizes breast cancer cells to retinoic acid: evidence of transcriptional crosstalk. 15383631

2004