Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. 19124506

2009
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Cyclin D1 expression is associated with poor prognostic features in estrogen receptor positive breast cancer. 18240019

2009
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists. 18632615

2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. 18456656

2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN The helix-loop-helix protein Id1 requires cyclin D1 to promote the proliferation of mammary epithelial cell acini. 18413773

2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1. 17941827

2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy. 18347178

2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Tumor susceptibility and prognosis of breast cancer associated with the G870A polymorphism of CCND1. 18043898

2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN CCND1 amplification and cyclin D1 expression in breast cancer and their relation with proteomic subgroups and patient outcome. 17653856

2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 GeneticVariation LHGDN Polymorphisms of HER2 Ile655Val and cyclin D1 (CCND1) G870A are not associated with breast cancer risk but polymorphic allele of HER2 is associated with nodal metastases. 18237245

2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. 17344214

2007
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. 17486065

2007
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation. 17935714

2007
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Polymorphisms in XRCC1, XRCC3, and CCND1 and survival after treatment for metastatic breast cancer. 17116943

2006
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells. 15735724

2005
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Immunohistochemical evaluation of cyclin D1 in breast cancer. 15861516

2005
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. 12883688

2004
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter. 15282324

2004
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Cyclin d1 overexpression sensitizes breast cancer cells to fenretinide. 12738746

2003
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Aberrant expression of cell-cycle regulator cyclin D1 in breast cancer is related to chromosomal genomic instability. 12007188

2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node. 12096344

2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells. 11948404

2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Involvement of G1/S cyclins in estrogen-independent proliferation of estrogen receptor-positive breast cancer cells. 12444551

2002