Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN Pre-transplant AFP and the dynamic change of AFP after LT were valuable in predicting tumor recurrence after LT for patients with HCC. 18563566

2009

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN Interestingly, AFP-specific T cells were not only found in patients with HCC but also in patients with chronic HCV infection, other liver diseases, and less frequently in healthy subjects. 19003875

2008

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN Using HPLC and MALDI-TOF MS, we determined the N-glycan structures of AFP from HCC cell lines, and demonstrated they were affected by N-acetylglucosaminyltransferase III and fucosyltransferase VIII, but not by N-acetylglucosaminyltransferase V. Moreover, we identified the N-glycan structures of AFP in HCC patients. 18479159

2008

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein. 18407604

2008

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN In this study, we show that the frequency of AFP(46-55) CD4(+) T cells is significantly higher (p = 001) in patients with hepatocellular carcinoma than in healthy donors, suggesting that these cells are expanded in response to tumor Ag. 18354237

2008

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 GeneticVariation LHGDN The results indicated that substitution of aa 70 of HCV-1b core region is an important predictor of elevated AFP in non-HCC patients, and that eradication of the mutant virus normalizes AFP. 18551609

2008

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN The alpha-fetoprotein-positive cases also showed a significantly higher microvessel density than alpha-fetoprotein-negative cases (P = 0.035), whereas hepatocellular carcinoma without alpha-fetoprotein overexpression had a higher apoptotic index when compared to hepatocellular carcinoma with alpha-fetoprotein overexpression (P = 0.033). 18466288

2008

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN Taken together, we proposed an easy classification system defined by EpCAM and AFP to reveal HCC subtypes similar to hepatic cell maturation lineages, which may enable prognostic stratification and assessment of HCC patients with adjuvant therapy and provide new insights into the potential cellular origin of HCC and its activated molecular pathways. 18316609

2008

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN Unmasking of alpha-fetoprotein-specific CD4(+) T cell responses in hepatocellular carcinoma patients undergoing embolization. 17237442

2007

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN Alpha-fetoprotein mRNA detection in peripheral blood for prediction of hepatocellular carcinoma recurrence after liver transplantation. 17175354

2006

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN h-TERT mRNA seemed to prove more valuable than AFP mRNA not only to assess preoperative treatment modalities and postoperative patient surveillance, but also to evaluate prospective LDLT patients with HCC. 17175353

2006

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN In conclusion, these results illustrate that AFP induces dysfunction and apoptosis of APCs, thereby offering a mechanism by which HCC escapes immunological control. 15265907

2004

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN The data indicate that AFP can stimulate the expression of some oncogenes to enhance the proliferation of human hepatocellular carcinoma Bel 7402 cells. 15040024

2004

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN We therefore conclude that AFP elevation, more than a coincidental epiphenomenon, appears to contribute to vascular invasion and HCC progression and help to identify subsets of HCC patients with increased risk for early recurrence and poor prognosis after hepatectomy. 15305374

2004

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN This study showed a significant relationship between the intensity and percentage of cells stained in hepatitis B, cirrhosis and HCC for GST-pi immunoreactivity (P < .001, .001 and .05, respectively) but not for AFP (P > .05). 14714299

2003