Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 AlteredExpression LHGDN Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling. 17962701

2008
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 AlteredExpression LHGDN TLR 5, but neither TLR2 nor TLR4, is involved in lung epithelial cell response to Burkholderia cenocepacia. 18680520

2008
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 AlteredExpression LHGDN Helicobacter pylori infection affects Toll-like receptor 4 expression in human gastric mucosa. 18251133

2008
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 Biomarker LHGDN Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. 17916356

2007
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 GeneticVariation LHGDN Toll-like receptor 4 Asp299Gly polymorphism is associated with an increased risk of pancreatic necrotic infection in acute pancreatitis: a study in the Chinese population. 17414051

2007
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 Biomarker LHGDN Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. 17992260

2007
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 GeneticVariation LHGDN Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection. 16613760

2006
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 GeneticVariation LHGDN TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease. 17264400

2006
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 AlteredExpression LHGDN Reduced expression of Toll-like receptor 4 contributes to impaired cytokine response of monocytes in uremic patients. 16738534

2006
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 AlteredExpression LHGDN Monocyte toll-like receptor 4 expression and LPS-induced cytokine production increase during gestational aging. 15879290

2005
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 AlteredExpression LHGDN Superantigen recognition by HLA class II on monocytes up-regulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin. 15644417

2005
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 Biomarker LHGDN Characterization of Toll-like receptors in the female reproductive tract in humans. 15695310

2005
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 AlteredExpression LHGDN Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kappa B, ERK 1/2 and p38 MAPK in host monocytes. 14706103

2004
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 Biomarker LHGDN Gastric mucosal recognition of Helicobacter pylori is independent of Toll-like receptor 4. 12599057

2003
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3714514
Disease: Infection
Infection 		0.100 GeneticVariation LHGDN Role of the toll-like receptor 4 Asp299Gly polymorphism in susceptibility to Candida albicans infection. 12402214

2002