Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response. 22958920

2012

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD BTBR Ob/Ob mutant mice model progressive diabetic nephropathy. 20634301

2010

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse. 19528970

2009

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation. 19620723

2009

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. 19103808

2008

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. 17550780

2007

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes. 17068142

2007

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Increased pulmonary responses to acute ozone exposure in obese db/db mice. 16373670

2006

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress. 16469807

2006

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Leptin is a circulating hormone and major adiposity signal involved in long-term energy homeostasis. 16293682

2006

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. 16326714

2006

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch. 16612592

2006

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Severe pulmonary metastasis in obese and diabetic mice. 16998795

2006

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice. 16394172

2006

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. 12885755

2003

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Leptin-deficient mice of the DBA-ob strain have variable obesity-diabetes. 12136396

2002

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci. 11078464

2000

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Early treatment of obese (ob/ob) mice with triiodothyronine increases oxidative metabolism in muscle but not in brown adipose tissue or liver. 7815168

1995

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. 7560100

1995

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. 8177042

1994

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Early treatment of obese (ob/ob) mice with triiodothyronine increases oxygen consumption and temperature and decreases body fat content. 7800681

1994

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD Diminished epinephrine excretion in genetically obese (ob/ob) mice and monosodium glutamate-treated rats. 1382044

1992

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker MGD The influence of genetic background on the expression of the obese (Ob) gene in the mouse. 4588246

1973