Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD The cardiovascular phenotype of a mouse model of acromegaly. 19269870

2009

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. 16174655

2006

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Comparing adiposity profiles in three mouse models with altered GH signaling. 15231300

2004

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Puberty is delayed in male growth hormone receptor gene-disrupted mice. 12185100

2003

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Impact of growth hormone resistance on female reproductive function: new insights from growth hormone receptor knockout mice. 12297526

2002

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. 11133160

2001

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice. 11336996

2001

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice. 10974652

2000

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD We chose to study the effects of loss of GH signaling on growth and aging in a mouse model for Laron Syndrome (LS) in which the GHR/BP gene has been disrupted. 10875265

2000

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Protection against diabetes-induced nephropathy in growth hormone receptor/binding protein gene-disrupted mice. 10614635

2000

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/- mice. 10631109

2000

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Deficits in female reproductive function in GH-R-KO mice; role of IGF-I. 10342852

1999

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD Pituitary and testicular function in growth hormone receptor gene knockout mice. 10067829

1999

Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0271568
Disease: Laron Syndrome
Laron Syndrome
1.000 Biomarker MGD These findings indicate that the GHR/BP-deficient mouse (Laron mouse) is a suitable model for human Laron syndrome that will prove useful for the elucidation of many aspects of GHR/BP function that cannot be obtained in humans. 9371826

1997