Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker PSYGENET In a nutshell, transition of a single nucleotide may modify differential DNA-protein interactions at OPRK1 and PDYN?s SNPs, significantly associated with pathology that may lead to altered individual vulnerability for alcohol dependence. 25177835

2015

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker PSYGENET These findings support the hypothesis that sequence variation in the PDYN gene contributes to both alcohol dependence and the induction of negative craving in alcohol-dependent subjects. 23101464

2014

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker PSYGENET Thus, the data obtained suggest no association of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN with alcoholism in Croatian population. 24035285

2014

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker PSYGENET Our findings could help to the understanding of how alcohol differentially affects the opioid systems in the brain and also suggest the dynorphin and nociceptin systems as possible targets for the treatment and/or prevention of alcohol dependence. 21507157

2013

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker PSYGENET These results indicate that variation in the PDYN gene is associated with a dimensional trait or intermediate phenotype that reflects a preference for heavy drinking and engaging in related risky behaviors (e.g., drug use, sexual activity). 21736916

2012