Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene, which are involved in dopamine metabolism, and the methylenetetrahydrofolate reductase (MTHFR) gene, which may affect COMT methylation and COMT function. 25744938

2015

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET Genotyping for COMT polymorphisms was carried out by DNA direct sequencing in 112 patients (54 MDD and 58 BD) and 58 healthy subjects. 25766270

2015

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET The negative effects of antipsychotics on cognitive functioning in bipolar disorder may be moderated by the COMT Val 108/158 Met genotype, with a negative effect of Val allele load. 23421957

2013

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes. 23861766

2013

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET A gene coexpression network was developed based on a mutual information approach including four candidate genes (NRG1, DISC1, BDNF and COMT) along with other coexpressing genes in unipolar disorder, bipolar disorder and schizophrenia. 22777684

2012