Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Among all candidate substrates, DPP4 displays highest affinity for NPY, an endogenous anxiolytic neurotransmitter that is suggested as a candidate biomarker in post-traumatic stress disorder (PTSD) and depression. 25635612

2015

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Using a recombinant adeno-associated viral (rAAV) vector, we addressed this idea by testing effects on anxiolytic- and depression-like behaviours in adult mice after overexpression of NPY transgene in the amygdala and/or hippocampus, two brain regions implicated in emotional behaviours. 25267070

2014

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript. 23697793

2013

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Statistical analysis showed a significant correlation between the SNP sites rs16139 in NPY and the morbidity of depression. 23468908

2013

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET No significant differences in NPY IgG autoAb affinities between patients with depression and controls were found, but higher affinity of IgG autoAbs for NPY was associated with lower body mass index and prevented NPY-induced orexigenic response in mice after their central injection. 22365482

2012