Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker PSYGENET Here we show that tamoxifen-induced GluA1 deletion restricted to forebrain glutamatergic neurons of post-adolescent mice does not induce depression- and anxiety-like changes. 24895223

2015

Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker PSYGENET The ?p35KI mice exhibit impaired long-term depression and defective memory extinction, likely mediated through persistent GluA1 phosphorylation at Ser845. 24725413

2014

Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker PSYGENET Down-regulation of ?CaMKII levels, blocking its activity or its target molecule the glutamate receptor GluR1 reversed the depressive symptoms. 23990563

2013

Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker PSYGENET We also found that depression of the closed eye response that normally occurs in the monocular as well as binocular zone is delayed, but only in the monocular zone in GluA1(-/-) mice and only in a background strain we have previously shown lacks synaptic scaling (C57BL/6OlaHsd). 24048851

2013

Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker PSYGENET Our results provide evidence for a significant role of hippocampal GluA1-containing AMPA receptors and their PDZ-interaction in experience-dependent expression of behavioral despair and link mechanisms of hippocampal synaptic plasticity with behavioral expression of depression. 23262314

2013