Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Ketamine suppressed the production of the only established depression-relevant proinflammatory cytokines, IL-6 and TNF?. 25903726

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET These observations demonstrate that IL6 directly controls SERT levels and consequently serotonin reuptake and identify STAT3-dependent regulation of SERT as conceivable neurobiological substrate for the involvement of IL6 in depression. 25760924

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET However, the expression of DNMT1/3A, EZH2 and IL-6 genes increases with increasing Hospital Anxiety and Depression Scale-Anxiety scores in the anxious cohort only. 25350786

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Changes in the mRNA expression of inflammatory cytokines, including interleukin (IL)-1?, tumor necrosis factor-?, IL-6, and interferon-?, were not correlated with the decrease in hippocampal neurogenesis or the appearance of depression-like behavior during the chronic phase following irradiation. 24491956

2014

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET The homeostatic functions of IL-6 imply that ubiquitous IL-6 inhibitors, for example, tocilizumab, may not be the optimal treatment target in depression. 24548241

2014