Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker PSYGENET TREK1 knockout mice have impaired PUFA-mediated neuroprotection to ischemia, reduced sensitivity to volatile anesthetics, altered perception of pain, and a depression-resistant phenotype. 21262820

2011
Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker PSYGENET Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans. 19621370

2010
Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker PSYGENET In mice, deletion of the TREK-1 gene results in a depression-resistant phenotype that mimics antidepressant treatments. 20405001

2010
Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker PSYGENET TREK1 knockout mice display impaired polyunsaturated fatty acid-mediated protection against brain ischemia, reduced sensitivity to volatile anesthetics, resistance to depression and altered perception of pain. 18998088

2008
Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker PSYGENET The mammalian K2P2.1 potassium channel (TREK-1, KCNK2) is highly expressed in excitable tissues, where it plays a key role in the cellular mechanisms of neuroprotection, anesthesia, pain perception, and depression. 18474599

2008