Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Among all candidate substrates, DPP4 displays highest affinity for NPY, an endogenous anxiolytic neurotransmitter that is suggested as a candidate biomarker in post-traumatic stress disorder (PTSD) and depression. 25635612

2015

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Using a recombinant adeno-associated viral (rAAV) vector, we addressed this idea by testing effects on anxiolytic- and depression-like behaviours in adult mice after overexpression of NPY transgene in the amygdala and/or hippocampus, two brain regions implicated in emotional behaviours. 25267070

2014

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript. 23697793

2013

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Statistical analysis showed a significant correlation between the SNP sites rs16139 in NPY and the morbidity of depression. 23468908

2013

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET These data suggest that changes of plasma levels of anti-NPY autoAbs are relevant to altered mood, while changes of their affinity may participate in altered appetite and body weight in patients with depressive disorder. 22365482

2012