Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7425
Gene Symbol: VGF
VGF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1?, IL-1?, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-?), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study. 22990943

2013

Entrez Id: 7425
Gene Symbol: VGF
VGF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET Recent studies demonstrate that the neuropeptide VGF (nonacronymic) is regulated in the hippocampus by antidepressant therapies and animal models of depression and that acute VGF treatment has antidepressant-like activity in animal paradigms. 20631166

2010

Entrez Id: 7425
Gene Symbol: VGF
VGF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET We summarize experimental data describing the roles of BDNF, VGF and other neuropeptides in depression and how they may be acting through the generation of new neurons and altered synaptic activity. 18983874

2009

Entrez Id: 7425
Gene Symbol: VGF
VGF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET Although LTP was normal in slices from VGF knock-out mice, LTD could not be induced, and VGF mutant mice were impaired in hippocampal-dependent spatial learning and contextual fear conditioning tasks. 18815270

2008