Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker PSYGENET Method We investigated the associations between SSEPs and polymorphisms within candidate genes of the serotonergic, GABAergic as well as the substance P system in subjects at high risk for affective disorders. 22225676

2013

Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker PSYGENET In this study, we used macroarrays to investigate the differential gene expression profile induced by SP, particularly of genes which have been shown to be involved in the pathophysiology of affective disorders. 16806114

2006

Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker PSYGENET Results from preclinical and human studies implicate SP and its pathway in the pathophysiology of mood disorders. 15927090

2005

Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker PSYGENET The results confirm an involvement of the tachykinins in psychiatric disorders, suggesting there is a generalized impairment of the SP system in the amygdala in mood disorders and schizophrenia rather than this being a disease-related phenomenon. 15845098

2005

Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker PSYGENET More recently, the neuropeptide substance P (SP) and its receptor (the neurokinin-1 receptor [NK1R]) have been implicated in the pathophysiology of affective disorders, including depression. 12562138

2002