Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET To investigate the possible contribution of rare variants to the development of substance dependencies other than nicotine dependence, specifically alcohol and cocaine dependence, we undertook pooled sequencing of the coding regions and flanking sequence of CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 in 287 African American and 1028 European American individuals from the Collaborative Study of the Genetics of Alcoholism (COGA). 24057674

2014

Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET The strongest association signal in either sample was between rs684513 in CHRNA5 and cocaine dependence (OR=1.43, P=0.0004) in the AA replication set. 20485328

2010

Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET In the FSCD, there was a significant association between the CHRNA5 variant and cocaine dependence (odds ratio = .67 per allele, p = .0045, assuming an additive genetic model), but in the reverse direction compared with that previously observed for nicotine dependence. 18519132

2008

Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET We applied this method to correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in a case-control study of cocaine dependence composed of 504 European-American and 583 African-American samples. 18759969

2008