Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Here, we examined whether the OPRK1 rs6989250 C>G affects stress-induced cocaine craving and cortisol responses, subsequent cocaine relapse risk and the neural response to stress using functional magnetic resonance imaging (fMRI) in cocaine dependence. 23962922

2014

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET This study indicates that a patient's OPRK1 genotype could be used to identify a subset of individuals for whom vaccine treatment may be an effective pharmacotherapy for cocaine dependence. 23995774

2014

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Moreover, seven SNPs covering OPRK1 were examined in the majority of the above subjects (390 cases, including 327 AD, 177 CD and 97 OD subjects, and 358 controls). 17622222

2008

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Evidence suggests that the kappa-opioid receptor (KOP-r) system plays an important role in cocaine addiction. 17532787

2007

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET Findings from these studies have led us to recognize the profound disruption of both dynorphin gene expression and kappa opioid receptor gene expression in a setting of chronic cocaine administration and, in turn, have led us to question a possible role of disruption of this system in the acquisition and persistence of cocaine addiction. 8943583

1997