Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET These results suggest that dynorphin in a very specific area of the nucleus accumbens contributes to depressive-like states and may be involved in neuroadaptations in the NAcc that contribute to the development of cocaine addiction as a persistent and lasting condition. 24816773

2015

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET In this study, 3 polymorphisms in PDYN (rs1022563, rs910080 and rs1997794) were genotyped in opioid-addicted [248 African Americans (AAs) and 1040 European Americans (EAs)], cocaine-addicted (1248 AAs and 336 EAs) and control individuals (674 AAs and 656 EAs). 22443215

2012

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET This study provides evidence that a 3'UTR PDYN haplotype, implicated in vulnerability to develop cocaine addiction and/or cocaine/alcohol codependence, is related to lower mRNA expression of the PDYN gene in human dorsal and ventral striatum. 18923396

2009

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. 16184603

2006

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Our results suggest that this allelic variation at the promoter region of the prodynorphin gene (alleles with three or four repeats), which may result in enhanced transcription of the gene, may contribute to relative protection and decrease individual vulnerability to develop cocaine dependence or abuse. 11992566

2002