Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET In conclusion, polymorphisms in the CREB gene may not be independently associated with MDD risk, but they are likely to confer increased susceptibility by interacting with environmental risk factors in the Chinese population. 25755794

2015

Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET In the current study, we explored the effect of the pathogenic Creb1 allele on gene expression in the mouse hippocampus, a brain region that is altered in structure and function in MDD. 25059218

2015

Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET This work also predicted that the genes with the greatest impact on model stability were those involved in the neurotrophin pathway, such as CREB, BDNF (which has been associated with major depressive disorder in a variety of studies) and TRkB, followed by genes and metabolites related to 5-HT synthesis. 24093582

2014

Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET This study aimed to investigate the influence of CREB1 polymorphism on cognitive function in patients with MDD. 23844928

2014

Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET This was achieved by replacing the corresponding mouse DNA sequence with a 6-base DNA sequence from the human CREB1 promoter that is associated with the development of MDD in men and women from families identified by probands with recurrent, early-onset MDD (RE-MDD). 24006268

2014