Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder. 23529111

2013

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET The corticotropin-releasing hormone (CRH) system coordinates neuroendocrine and behavioral responses to stress and has been implicated in the development of major depressive disorder (MDD). 22378896

2012

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET In addition, persistent elevation of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) concentrations following early-life adversity has been posited to underlie the subsequent development of major depression. 20692103

2011

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Gene x environment (G x E) interactions mediating depressive symptoms have been separately identified in the stress-sensitive serotonergic (5-HTTLPR) and corticotropin-releasing hormone (CRHR1) systems. 20029939

2010

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Our results suggest that the aberrant REST-mediated transcriptional regulation of, at least, CRH, adenylate cyclase 5, and tumor necrosis factor superfamily, member 12-13, might be state-dependent and associated with the pathophysiology of major depression. 19846118

2010