Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2668
Gene Symbol: GDNF
GDNF
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.370 Biomarker PSYGENET Genotyping for BDNF and GDNF polymorphisms was performed in 298 patients with MDD who started 20 mg paroxetine per day and had their plasma concentrations measured after 6 weeks. 24577123

2014

Entrez Id: 2668
Gene Symbol: GDNF
GDNF
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.370 Biomarker PSYGENET Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases. 22152193

2012

Entrez Id: 2668
Gene Symbol: GDNF
GDNF
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.370 Biomarker PSYGENET We suggest that following AD treatment, β-arrestin1 generates a transcription complex involving CREB essential for GDNF expression and release, thus enhancing GDNF's neuroprotective action that promotes cellular survival and plasticity when the survival and function of neurons is compromised as occurs in major depression. 21223624

2011

Entrez Id: 2668
Gene Symbol: GDNF
GDNF
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.370 Biomarker PSYGENET Our results suggest that the changes in the expression levels of GDNF, ARTN, and NT-3 mRNAs might be state-dependent and associated with the pathophysiology of major depression. 18313696

2008