Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population. 24262814

2015

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Here, we aimed to assess how recently associated PCLO and CACNA1C depression risk alleles jointly affect memory-related CG25 activity as an intermediate phenotype in clinically healthy humans. 24643163

2015

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24642287

2015

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24411473

2015

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET The current data provide further evidence for an impact of rs1006737 on the left IFG and demonstrate that genetic variation in CACNA1C modulates neural responses in patients with MDD. 24612926

2014