Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker PSYGENET Ongoing research has identified a region of the HTR2A promoter that has been associated with a number of medical outcomes in adults and infants, including bipolar disorder, schizophrenia, chronic fatigue syndrome, borderline personality disorder, suicidality, and neurobehavioral outcomes. 25043477

2015

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker PSYGENET A number of studies have assessed a relationship between the T102C polymorphism in the HTR2A gene with an increased risk of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ). 24962835

2015

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.800 Biomarker PSYGENET The results of our analysis indicated no significant differences in the frequencies of the single alleles and genotypes of two polymorphisms in TPH2 gene between LOD patients and normal controls. 26057341

2015

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.800 Biomarker PSYGENET Single locus analysis in pooled and ethnically stratified subjects revealed no association between each of the three variants of the TPH2 gene with susceptibility to MDD. 24376086

2015

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.800 Biomarker PSYGENET Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. 24196946

2014

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker PSYGENET We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD. 23404241

2013

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker PSYGENET Our findings provide initial evidence that the ALDH2 and 5-HT2A genes interact in bipolar-I but not in bipolar-II disorder. 22564712

2013

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.800 Biomarker PSYGENET Here we use chronic multicircuit neurophysiological recordings to characterize functional interactions across cortical and limbic circuits in mice engineered to express a human loss-of-function depression allele Tph2-(R441H) [Tph2 knockin (Tph2KI)]. 23467366

2013

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.800 Biomarker PSYGENET A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (R439H Tph2 KI) show 80% reduction in 5-HT synthesis and tissue levels. 23336047

2013

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker PSYGENET Epigenetic dysregulation of HTR2A may contribute to SCZ, BD and earlier age of disease onset. 21550210

2011

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.710 Biomarker PSYGENET Higher mean serum S100B levels were associated with the risk G allele of rs3788266 in BPAD cases (P = 0.0001), unaffected relatives of BPAD cases (P < 0.0001) and unrelated controls (P < 0.0001). 21714070

2012

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.710 Biomarker PSYGENET Recently, associations were found between variations in the S100B gene and schizophrenia as well as bipolar affective disorder. 21112154

2011

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.710 Biomarker PSYGENET These genes include GRM7, previously associated to major depression disorder and bipolar disorder, SLC6A13, in anxiety disorders, and S100B, SSTR5 and COMT in schizophrenia. 20398908

2011

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.710 Biomarker PSYGENET The role of DRD2 and NPY on alcohol dependence was also supported. 20554694

2010

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.710 Biomarker PSYGENET Overall, our findings suggest that variants within the S100B gene predispose to a psychotic subtype of BPAD, possibly via alteration of gene expression. 17525977

2008

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.710 Biomarker PSYGENET Therefore, decreased function of CREB in the central nucleus of the amygdala might regulate anxiety and alcohol intake via decreased expression of NPY, and might provide a common link between anxiety and alcohol abuse disorders. 12967770

2003

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker PSYGENET With few exceptions like ALDH2*2, the contribution of individual genetic variants to the risk for alcohol-related disorders is small. 25359488

2015

Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker PSYGENET It has been well documented that variant alleles of both ADH1B*2 of alcohol dehydrogenase (ADH) and ALDH2*2 of aldehyde dehydrogenase (ALDH) protect against the development of alcoholism in East Asians. 25365528

2015

Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker PSYGENET We developed a time- and cost-effective multiplex allele-specific polymerase chain reaction (AS-PCR) method based on the two-step PCR thermal cycles for genotyping single-nucleotide polymorphisms in three alcoholism-related genes: alcohol dehydrogenase 1B, aldehyde dehydrogenase 2 and ?-opioid receptor. 25382047

2015

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker PSYGENET Our findings suggest that the interplay between ALDH2?2 and drinking-related problems is complex, involving both mediation and moderation processes that reduce the likelihood of developing problems via reduction of heavy drinking as well as by altering the relationship between alcohol consumption and problems. 24661165

2015

Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker PSYGENET We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively. 25410943

2015

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker PSYGENET We investigated whether variation in genes encoding cytochrome P450 2E1 (CYP2E1) or acetaldehyde-metabolising enzymes (ALDH1A1, ALDH2) might alter the risk of AD, with and without symptoms of anxiety, in a Cape population with mixed ancestry. 24567230

2015

Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker PSYGENET Indo-T with at least one ADH1C*2 allele may be at higher risk for heavy drinking by feeling less of the effects of alcohol, including nausea. 25208201

2015

Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker PSYGENET ADH1C*2 allele may contribute to the variance in heritability of alcohol dependence. 25372623

2015

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker PSYGENET To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample. 25372623

2015