Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 CausalMutation CGI

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 Biomarker HPO

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 Biomarker BEFREE Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer. 6292117

1982

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE Immunohistochemical data suggest that p53 mutation is the commonest genetic alteration so far detected in primary breast cancer. 1694291

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 Biomarker BEFREE The p53 gene initially was thought to be an oncogene, but recent evidence suggests that wild-type p53 can function as a tumor suppressor gene in lung, colon, and breast cancer as well as less common malignancies. 2164047

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE Mutation of the p53 gene with over-expression of the mutant protein is therefore one of the most frequent specific genetic changes in malignant breast cancer. 2228312

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 Biomarker BEFREE Furthermore, the result of the deletion mapping on chromosome 17p implied the existence of a tumor suppressor gene distal to the p53 gene as well as the p53 gene itself for primary breast cancer. 1977515

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 Biomarker BEFREE Thus, abnormal p53 is the commonest oncogene abnormality described in breast cancer. 1685017

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 Biomarker BEFREE The p53 gene, a putative tumor suppressor gene located at 17p13, was examined for aberrations to determine whether it is the target for the 17p LOH in breast cancer. 1673792

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 AlteredExpression BEFREE Genetic basis for p53 overexpression in human breast cancer. 2052583

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE Maintenance of p53 alterations throughout breast cancer progression. 1850660

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE We conclude that, compared to amplification of HER2/NEU, MYC, or INT2 oncogene loci, p53 gene mutations and deletions are the most frequently observed genetic change in breast cancer related to a single gene. 1961733

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 AlteredExpression BEFREE The CDGE technique was then used to screen 32 breast carcinomas that had been analyzed by immunohistochemical methods for altered p53 protein levels and whose DNA had already been shown to have loss of heterozygosity for a chromosome 17p marker. 1924299

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 AlteredExpression BEFREE The presence of elevated levels of mutant p53 may itself be a prognostic factor in human breast cancer and activation of this oncogene may be important in the ability of a tumor to metastasize. 1858036

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE Immunohistochemical analysis is a simple method which reliably predicts the presence of most p53 gene mutations in breast cancer specimens. 1745051

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE There was no significant correlation with c-erbB-2 protein expression or retinoblastoma protein loss. p53 protein was detected in a high proportion of cells in three of the six comedo ductal carcinomas in situ studied but either not at all or at a lower level in tumours of the cribriform type. p53 mutations are common in breast carcinomas, but heterogeneity within individual tumours is frequent. 1684809

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 AlteredExpression BEFREE In 86% of breast carcinoma samples where both allele loss and expression data were available, loss of sequences on 17p13 and/or expression of p53 was detected. 2011397

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 Biomarker BEFREE The cell lines MDA-MB 468 and T47 D contain only single mutated copies of the p53 gene, whereas the status of p53 in the breast cancer cell line MCF 7 remains equivocal. 1923504

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE Direct sequencing from touch preparations of human carcinomas: analysis of p53 mutations in breast carcinomas. 1712853

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 Biomarker BEFREE Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. 1353891

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families. 1570151

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 AlteredExpression BEFREE Retinoblastoma and p53 gene product expression in breast carcinoma: immunohistochemical analysis and clinicopathologic correlation. 1468776

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE Some recent data on the Wilms' tumor gene, WT1, and on the involvement of the p53 gene in breast cancer are presented, and the importance of genomic imprinting in contributing to the excess of suppressor gene mutations in chromosomes of paternal origin is considered. 1336726

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE One germ-line mutation was found in 136 patients and so we conclude that constitutional mutation of p53 may be an uncommon etiological factor in breast cancer. 1394133

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 GeneticVariation BEFREE We examined 126 consecutive patients who developed breast cancer at or before the age of 40 for mutations of p53 within conserved regions of the gene. 1581912

1992