Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Genome-wide scans have mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located. 11756320

2002

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Serum high-sensitivity C-reactive protein (hsCRP) and the ratio of high-molecular-weight (HMW)/total adiponectin were positively associated with ADS-L in T2D (both P<0.01), but not in T1D. 28041985

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE We studied three adiponectin polymorphisms (-11391G > A, +45T > G and +276G > T) in 3086 subjects with type 2 diabetes and high levels of albumin excretion from the diabetes, hypertension, microalbuminuria or proteinuria, cardiovascular events and ramipril (DIABHYCAR) trial. 20083470

2010

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes. 16352688

2006

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Potential underlying biological mechanisms linking diet quality and T2D risk are an improved lipid profile and reduced systemic inflammation and, with regards to DASH alone, an improved adiponectin profile. 28875870

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE ADIPOQ, encoding adiponectin, is a candidate gene for type 2 diabetes (T2D) identified by genome-wide linkage analyses with supporting evidence showing the protein function in sensitizing insulin actions. 22046359

2011

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The 276G>T polymorphism of the adiponectin (ADIPOQ) gene has been correlated with plasma adiponectin, type 2 diabetes (T2D) and its complications. 22222620

2012

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE This study aimed to investigate gene-environment interactions among moderate/severe periodontitis, polymorphisms of adiponectin (ADIPOQ)-rs1501299, and leptin receptor (LEPR)-rs1137100 on T2DM risk in Chinese subjects. 31128439

2019

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Patients with T2D have significantly higher levels of A-FABP and lower levels of adiponectin. 29717906

2018

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Low serum adiponectin level may precipitate liver steatosis in patients with type 2 diabetes. 26042596

2015

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE We analysed baseline adiponectin concentration and CV outcomes in 5213 patients with type 2 diabetes enrolled in the EXAMINE trial of alogliptin vs placebo 15 to 90 days (median 45 days) after ACS.Event rates at 18 months are reported. 28195387

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE In recent studies reported that several markers associated with insulin sensitivity in skeletal muscle, Adiponectin and other parameters, such as fatty acid-binding protein (FABP4), have been reported to regulate insulin resistance, but it remains unclear which factor mostly affects insulin resistance in T2DM. 28654680

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The present meta-analysis was performed to clarify the role of polymorphisms in proximal promoter region of ADIPOQ (rs17360539 and rs266729) in type 2 diabetes. 20580771

2010

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE However, adiponectin plasma concentrations are low in obese subjects, and hypoadiponectinemia is associated with the metabolic syndrome, which is a cluster of insulin resistance, type 2 diabetes mellitus, hypertension, and dyslipidemia. 12788102

2003

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE The study findings revealed that <i>B. integerrima</i> might be a protective candidate against Type 2 diabetes/insulin resistance through direct insulin-like effect and an increase in adiponectin levels.However, the mechanism of <i>B. integerrima</i> was independent of GLUT4 and PPARγ. 29147484

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Taken together, our data suggest that syringin attenuates HFD-induced insulin resistance through the suppressive effect of adiponectin on low-grade inflammation, lipotoxicity, and ER stress, and show syringin as a potential therapeutic agent for prevention and treatment of type 2 diabetes with low risk of adverse effects such as weight gain and dysregulated lipid metabolism. 28476623

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Linkage was also present after inclusion of adiponectin concentrations of siblings with type 2 diabetes not treated pharmacologically (total siblings 582, 182 families, 860 sib-pairs: LOD = 3.5). 12941784

2003

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Adiponectin was higher in patients with type 1 diabetes compared to patients with type 2 diabetes, but decreased with treatment with both BIL and glargine. 28587667

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE One intron SNP (rs13306519) in LEPR and one 3'UTR SNP (rs1063537) in ADIPOQ demonstrated a significant association with T2DM (P = 0.024 and 0.014 respectively). 24414038

2014

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Adiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM). 28721140

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE To clarify the associations between plasma adiponectin levels and ADIPOQ variants with type 2 diabetes incidence in a general Japanese population. 28407551

2017

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population. 24825737

2015

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Potentially functional polymorphisms in the peroxisome proliferator-activated receptor-γ (PPAR-γ) and retinoid X receptor-α (RXR-α) genes may alter T2DM risks by increasing the human adiponectin promoter activity in cells. 21284483

2011

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Therefore, modulation of adiponectin expression represents a promising target for prevention or treatment of several diseases including insulin resistance and type II diabetes. 26610729

2016

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The aim of the present study is to investigate the association between +45T>G and +276G>T polymorphisms of the adiponectin gene and both plasma adiponectin levels and carotid intima-media thickness in patients with diabetes mellitus type 2. 25294284

2014