Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1
Gene Symbol: A1BG
A1BG
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
0.010 Biomarker BEFREE GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis. 18973555

2009

Entrez Id: 1
Gene Symbol: A1BG
A1BG
CUI: C0013080
Disease: Down Syndrome
Down Syndrome
0.010 Biomarker BEFREE The identified proteins are involved in iron homeostasis (ceruloplasmin and transferin), lipid metabolism (zinc-α2-glycoprotein, retinol-binding protein 4 and apolipoprotein A1) and inflammation (complement C9, α-1B-glycoprotein, collagen α-1V chain) with critical relevance in the clinical outcome of DS. 21360684

2011

Entrez Id: 1
Gene Symbol: A1BG
A1BG
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.010 Biomarker BEFREE The results show that combination of negative modulation of GA isoforms arising from GLS gene with the introduction of the GLS2 gene product, GAB, may in the future provide a useful means to curb glioblastoma growth in situ. 24096582

2014

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE The release of [(3)H]D-aspartate ([(3)H]D-ASP) or [(3)H]GABA evoked by glycine from spinal cord synaptosomes was compared in mice expressing mutant human SOD1 with a Gly(93) Ala substitution ([SOD1-G93A(+)]), a transgenic model of amyotrophic lateral sclerosis, and in control mice. 12684256

2003

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
0.040 Biomarker BEFREE This phenomenon might have pathological relevance, because [(3)H]d-ASP release is enhanced in experimental ALS. 20132478

2010

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE We studied the release of [3H]d-aspartate ([3H]d-ASP) and endogenous glutamate evoked by glycine (GLY) or GABA from spinal cord synaptosomes in mice expressing a mutant form of human SOD1 with a Gly93Ala substitution ([SOD1-G93A(+)]), a transgenic model of amyotrophic lateral sclerosis, in mice expressing the non-mutated form of human SOD1 [SOD1+], and in non-transgenic littermates [SOD1(-)/G93A(-)]. 15885796

2005

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
0.040 Biomarker BEFREE The release of [3H]D-aspartate ([3H]D-ASP) or [3H]GABA evoked by glycine and that of [3H]D-ASP or [3H]glycine evoked by GABA from spinal cord synaptosomes were studied in SOD1-G93A(+) mice, a transgenic model of amyotrophic lateral sclerosis, SOD1(+) mice and SOD1(-)/G93A(-) animals. 15033338

2004

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0028754
Disease: Obesity
Obesity
0.040 AlteredExpression BEFREE Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes. 20541607

2010

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0028754
Disease: Obesity
Obesity
0.040 Biomarker BEFREE Variation in the human counterparts to these genes (OB, DB, TUB, and ASP, respectively) may contribute to human obesity, which is thought to have a substantial genetic component. 8772727

1996

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0028754
Disease: Obesity
Obesity
0.040 AlteredExpression BEFREE Taken together, the profile of C5L2 receptor, ASP gene expression and metabolic factors in adipose tissue from morbidly obese HAT subjects suggests a compensatory response associated with the increased plasma ASP and TG. 20105310

2010

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0028754
Disease: Obesity
Obesity
0.040 AlteredExpression BEFREE Mahoganoid effects on energy homeostasis are, therefore, most evident in the circumstances of epistasis to hypothalamic overexpression of ASP in A(y) and possible other obesity-causing mutations. 12438443

2003

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
Childhood Acute Lymphoblastic Leukemia
0.030 Biomarker BEFREE The goals of this study were to assess the pharmacokinetics and pharmacodynamics of ASP and to mathematically model the dynamics between ASP and asparagine (ASN) in relapsed ALL. 19741605

2009

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
Childhood Acute Lymphoblastic Leukemia
0.030 Biomarker BEFREE Since the Bayer preparation is no longer available for treatment of large series of patients with ALL, the present study was designed to prospectively evaluate coagulation and fibrinolytic changes in leukaemic children receiving different doses of Medac ASP, which is now available for treatment of childhood ALL. 8857948

1996

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
Childhood Acute Lymphoblastic Leukemia
0.030 Biomarker BEFREE In conclusion, the presence of TEL/AML1 gene fusion in childhood precursor B-lineage ALL does not seem to be associated with a high in vitro drug sensitivity, except for ASP, indicating that these patients could benefit from treatment schedules with significant use of this drug. 10910927

2000

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
Fibrodysplasia Ossificans Progressiva
0.020 Biomarker BEFREE Our results provide proof-of-principle that ASP-RNAi has potential therapeutic efficacy for the treatment of FOP. 22011642

2012

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
Fibrodysplasia Ossificans Progressiva
0.020 Biomarker BEFREE Thus, the siRNAs presented here may become novel therapeutic agents for FOP, and their induced ASP-RNAi may pave the way for the achievement of radical treatment of FOP and/or for the relief of its severe symptoms. 22130450

2012

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.010 GeneticVariation BEFREE Distribution of both TNFR2 196 R/R and TNFR1 +36 A/A genotypes in the ASP RA sample showed that both suspected genotypes were exclusive. 14872483

2004

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0019087
Disease: Hemorrhagic Disorders
Hemorrhagic Disorders
0.010 Biomarker BEFREE Inclusion of an Arg-Gly-Asp receptor-recognition motif into the capsid protein of rabbit hemorrhagic disease virus enables culture of the virus <i>in vitro</i>. 28381555

2017

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023418
Disease: leukemia
leukemia
0.010 Biomarker BEFREE The expression was compared between different types of leukemia and was studied in relation with clinical risk indicators and in vitro cytotoxicity of the MDR-related drugs daunorubicin (DNR), vincristine (VCR), and etoposide (VP16) and the non-MDR-related drugs prednisolone (PRD) and L-asparaginase (ASP). 9490695

1998

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.010 GeneticVariation BEFREE Thrombotic events (TEs) are serious secondary complications in children with acute lymphoblastic leukemia (ALL) who receive L-asparaginase (ASP) therapy; however, the prevalence of TEs has not been established. 12518376

2003

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia
0.010 Biomarker BEFREE This review focuses on the recent discovery of retroviral antisense genes termed HBZ [in human T-cell leukemia virus type 1 (HTLV-1)] and ASP (in HIV-1) in terms of their function and the regulation of their expression, both of which are interconnected with the expression and function of other viral proteins. 25701112

2016

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0024530
Disease: Malaria
Malaria
0.010 GeneticVariation BEFREE The blood group of 60 healthy blood donors and 51 P. knowlesi malaria patients were genotyped using allele specific polymerase chain reaction (ASP-PCR). 25268233

2015

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.010 Biomarker BEFREE L-ASP concentrations were non-toxic to either ovarian cancer or HMVEC lines in the time frame of the assays. 22333033

2013

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.010 GeneticVariation BEFREE The data most supportive for linkage to schizophrenia were from chromosome 6q; logistic-regression analysis of linkage allowing for intersample heterogeneity produced an empirical P value <.0002 with, or P=.0004 without, inclusion of the sample that produced the first positive report in this region; the maximum NPL score in this region was 2.47 (P=.0046), the maximum LOD score (MLS) from ASP analysis was 3.10 (empirical P=.0036), and there was significant evidence for intersample heterogeneity (empirical P=.0038). 10924404

2000

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome
0.010 GeneticVariation BEFREE Extensive fragmentation of mtDNA was detected in association with increased 8-hydroxydeoxyguanosine content in the heart mitochondrial DNA (mtDNA) from a patient with premature aging and mitochondrial cardiomyopathy, who carried a mutation within the mitochondrial tRNA(Asp) gene. 8687011

1996