Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE Levels of the KAI1 metastasis suppressor are reduced in advanced stages of many human cancers, leading to the loss of KAI1 function. 17982617

2007

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE We have mapped the human prostate-specific membrane antigen (PSM) gene to the chromosome 11p11.2 region at 62.5 cM, a region which also contains the prostatic cancer metastasis suppressor gene KAI-1. 10705204

2000

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE Frequent down-regulation and lack of mutation of the KAI1 metastasis suppressor gene in epithelial ovarian carcinoma. 10873402

2000

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE Expressional alterations and transcript isoforms of metastasis suppressor genes (KAI1 and KiSS1) in breast cancer patients. 22320993

2011

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE Here, by using mass spectrometry, bioinformatics analysis and luciferase reporter assay, we showed that miR-K6-5p directly targeted the coding sequence of CD82 molecule (CD82), a metastasis suppressor. 28534512

2017

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE Genomic organization of the human KAI1 metastasis-suppressor gene. 9126478

1997

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE Promoter CpG-Site Methylation of the KAI1 Metastasis Suppressor Gene Contributes to Its Epigenetic Repression in Prostate Cancer. 27813113

2017

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE These results show that the suppressed invasion and motor function of pancreatic cancer cells may be a key reason why the KAI1 gene controls pancreatic cancer cell metastasis. 18286698

2008

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE Identification of the KAI1 metastasis suppressor gene as a hypoxia target gene. 20123085

2010

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE Expression of a splice variant of KAI1, a tumor metastasis suppressor gene, influences tumor invasion and progression. 14612520

2003

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI1 (also called CD82) is a metastasis suppressor gene known to be downregulated in breast cancer and other solid tumors. 30306427

2019

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE The cell-surface glycoprotein KAI1 suppresses tumor growth and metastasis in various animal models. 18712725

2008

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE In multivariate analysis, high VM, Notch4, DLL4 levels, tumor size, LNM, DM, TNM stage, and low KAI1/CD82 levels were potential to be independent prognostic factors for overall survival time (OST) in NSCLC patients.VM and the expression of Notch4, DLL4, and KAI1/CD82 represent promising markers for tumor metastasis and prognosis, and maybe potential therapeutic targets for NSCLC. 30593175

2018

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI1 tetraspanin and metastasis suppressor. 15618009

2005

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Tetraspanin CD82 is a wide-spectrum tumor metastasis suppressor that inhibits motility and invasiveness of cancer cells. 21685244

2011

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI1 is a newly discovered metastasis suppressor gene. 15312688

2004

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE CD82/KAI1 inhibits invasion and metastasis of esophageal squamous cell carcinoma via TGF-β1. 30280774

2018

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity. 15492270

2004

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Since the transforming growth factor β (TGF-β) and Wnt signals induce EMT in various epithelial cell types, we examined whether and how the CD82/KAI1 metastasis suppressor affects the TGF-β and Wnt signal-dependent EMT in human prostate cancer cells. 31212375

2019

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE The high frequency of KAI1-positive cases in ER-negative primary tumors was maintained in ER-negative metastases. 19549254

2009

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI1 is a metastasis suppressor gene which is capable of inhibiting the processes of tumor metastasis without affecting tumorigenicity per se. 10913345

2000

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE These results reemphasize the important role of MRP-1/CD9 and KAI1/CD82 in the suppression of the metastatic process and also show the feasibility of gene therapy when using these tetraspanins for lung cancer to prevent metastasis to the regional lymph nodes. 17308116

2007

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Recent studies suggest that complex mechanisms underlie CD82 loss of function, including altered transcriptional regulation, splice variant production and post-translational protein modifications, and indicate a central role for CD82 in controlling metastasis as a 'molecular facilitator'. 16271511

2005

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI1 COOH-terminal interacting tetraspanin (KITENIN) contributes to tumor invasion and metastasis in various cancers. 21418393

2011

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI-1/CD82, the molecule and clinical implication in cancer and cancer metastasis. 19224455

2009