Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE In nude mice, after feeding with VP-16, the number of tumors metastasized from spleen to liver was obviously reduced, and KAI1/CD82 protein expression became stronger in those metastatic tumors. 12955496

2003

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI1 (also called CD82) is a metastasis suppressor gene known to be downregulated in breast cancer and other solid tumors. 30306427

2019

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Correlation between reduction of metastasis in the MDA-MB-435 model system and increased expression of the Kai-1 protein. 9496911

1998

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE The cell-surface glycoprotein KAI1 suppresses tumor growth and metastasis in various animal models. 18712725

2008

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Additionally, advanced and metastasized tumor tissues revealed significantly down-regulated CD82 protein expression (p = 0.033 and p = 0, respectively), which correlated with the tumor pTNM stage (p = 0.001). 21521534

2011

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE In multivariate analysis, high VM, Notch4, DLL4 levels, tumor size, LNM, DM, TNM stage, and low KAI1/CD82 levels were potential to be independent prognostic factors for overall survival time (OST) in NSCLC patients.VM and the expression of Notch4, DLL4, and KAI1/CD82 represent promising markers for tumor metastasis and prognosis, and maybe potential therapeutic targets for NSCLC. 30593175

2018

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE To determine MRP-1/CD9 gene and KA11/CD82 gene expression, which have been postulated to be metastasis suppressor genes, we have applied quantitative RT-PCR. 10327061

1999

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI1 tetraspanin and metastasis suppressor. 15618009

2005

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE The human homolog, KAI1, is an activation antigen of T-cells and is a metastasis suppressor for prostate and other cancers. 16372335

2006

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Tetraspanin CD82 is a wide-spectrum tumor metastasis suppressor that inhibits motility and invasiveness of cancer cells. 21685244

2011

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI1 is a newly discovered metastasis suppressor gene. 15312688

2004

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE CD82/KAI1 inhibits invasion and metastasis of esophageal squamous cell carcinoma via TGF-β1. 30280774

2018

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity. 15492270

2004

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Moreover, loss of KAI1 expression significantly abrogated NDRG1-mediated metastatic suppression in vitro as well as in a spontaneous metastasis animal model, indicating that KA11 is a functional downstream target of the NDRG1 pathway. 21454613

2011

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Since the transforming growth factor β (TGF-β) and Wnt signals induce EMT in various epithelial cell types, we examined whether and how the CD82/KAI1 metastasis suppressor affects the TGF-β and Wnt signal-dependent EMT in human prostate cancer cells. 31212375

2019

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE The high frequency of KAI1-positive cases in ER-negative primary tumors was maintained in ER-negative metastases. 19549254

2009

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Impact of human papillomavirus infection on the expression of the KAI1 metastasis suppressor protein in invasive cervical cancer. 11146234

2001

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE Levels of the KAI1 metastasis suppressor are reduced in advanced stages of many human cancers, leading to the loss of KAI1 function. 17982617

2007

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI1 is a metastasis suppressor gene which is capable of inhibiting the processes of tumor metastasis without affecting tumorigenicity per se. 10913345

2000

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE We have mapped the human prostate-specific membrane antigen (PSM) gene to the chromosome 11p11.2 region at 62.5 cM, a region which also contains the prostatic cancer metastasis suppressor gene KAI-1. 10705204

2000

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis. 11895916

2002

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE These results reemphasize the important role of MRP-1/CD9 and KAI1/CD82 in the suppression of the metastatic process and also show the feasibility of gene therapy when using these tetraspanins for lung cancer to prevent metastasis to the regional lymph nodes. 17308116

2007

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Recent studies suggest that complex mechanisms underlie CD82 loss of function, including altered transcriptional regulation, splice variant production and post-translational protein modifications, and indicate a central role for CD82 in controlling metastasis as a 'molecular facilitator'. 16271511

2005

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE KAI1 COOH-terminal interacting tetraspanin (KITENIN) contributes to tumor invasion and metastasis in various cancers. 21418393

2011

Entrez Id: 3732
Gene Symbol: CD82
CD82
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Similarly, increased metastasis is seen in non small cell lung cancers following down regulation of nm23H1 in conjunction with KAI-1 down regulation. 19152459

2009