Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker LHGDN PIK3CA gene amplification in Japanese non-small cell lung cancer. 17681398

2007

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 AlteredExpression BEFREE The study suggests that HPV infection-induced IL-17 levels can stimulate Mcl-1 expression through the PI3K pathway and promote lung tumor cell progression through a p53- and IL-6-independent pathway. 20578176

2010

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation BEFREE The need for RAS interaction with p110α in the maintenance of mutant Kras-driven lung tumors was explored using an inducible mouse model. 24229709

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 AlteredExpression BEFREE Thus, in breast and lung tumor cells MDA-7 protein expression modulates cell-cell adhesion and intracellular signaling via coordinate regulation of the beta-catenin and PI3K pathways. 12907143

2003

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation BEFREE Actually, among the surgically resected lung tumors, the adenocarcinomas with the K-ras gene mutation tended to show a higher frequency and intensity of immunoreactivity for phosphorylated Akt (p-ser473Akt) than those without the mutation, supporting the in vitro observation that the mutated K-ras can activate the PI3K-Akt pathway. 14695323

2004

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 CausalMutation CGI

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation BEFREE Additionally, associations were found for EGFR variations in lung tumors and PIK3CA variations in breast tumors. 31100334

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker BEFREE Lung tumors were found to harbor PIK3CA (invasive lesions) and a rare in-frame insertion of nucleotides in exon 19 of EGFR (lepidic tumor). 30268473

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker BEFREE This robust automated bright-field dual in situ hybridization assay for the simultaneous detection of PIK3CA and CHR3 centromere provides a potential clinical diagnostic method to assess PIK3CA gene abnormality in lung tumors. 26163898

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation BEFREE Using GEM models, we tested whether PI3'-lipid signaling was limiting for the promotion of KRAS(G12D)-driven lung tumors by inducing the expression of KRAS(G12D) in the absence and presence of the activating PIK3CA(H1047R) mutation. 26567140

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation BEFREE We first observed that PD-0325901 at 1.5 mg/kg SID and in combination with PF-04691502 (7.5 mg/kg; SID) significantly inhibited growth of H460 (carry Kras and PIK3CA mutations) orthotopic lung tumors. 22684718

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker BEFREE The present study identifies that azithromycin targets VEGFR2-mediated focal adhesion and PI3K/Akt signaling pathways in HLT-ECs, leading to the suppression of angiogenesis and lung tumor growth. 28693139

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker BEFREE The p110α isoform of PI3K (encoded by Pik3ca) is an essential effector of oncogenic KRAS in murine lung tumors, but it is unknown whether p110α contributes to leukemia. 24569456

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 AlteredExpression BEFREE We analyzed the activation of the phosphatidyl inositol-3-kinase (PI3K)/AKT pathway and the mitogen-activated protein kinase/extracellular-signal regulated kinase (MAPK/ERK) pathway in lung tumors. 24374738

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation LHGDN Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. 19029981

2008

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker BEFREE Synchronous lung cancers from 60 patients (42 with adenocarcinoma and 18 with squamous cell carcinoma), clinically considered to represent intrapulmonary metastases, were histologically subtyped according to the 2015 World Health Organization classification of lung tumors and subjected to genotypic analysis (KRAS, EGFR, BRAF, PIK3CA, ALK, MET and ROS1 in adenocarcinoma and PIK3CA and p16 in squamous cell carcinoma). 27080983

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 GeneticVariation LHGDN PIK3CA mutations and copy number gains in human lung cancers. 18757405

2008