Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE <b>Background:</b> Phosphatidylinositol 3-kinase (PI3K) pathway activation plays a key role in tumorigenesis and has been associated with poor prognosis and resistance to multiple therapies in various cancers. 31741715

2019

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE <i>N</i>-Glycan deletion on β4-integrin impaired β4-dependent cancer cell migration, invasion, and growth <i>in vitro</i> and diminished tumorigenesis and proliferation <i>in vivo</i> The reduced abilities of β4-integrin were accompanied with decreased phosphoinositol-3 kinase (PI3K)/Akt signals and were restored by the overexpression of the constitutively active p110 PI3K subunit. 29549127

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE (2007) use mouse models of Ras-mediated tumorigenesis to show that the interaction of Ras with a single isoform of phosphatidylinositol 3-kinase (PI3K), called p110alpha (PIK3CA), is critical for tumor formation. 17540164

2007

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE (2008) identify specific functions of the p110beta isoform of PI3K in glucose metabolism, cellular proliferation, and tumorigenesis. 18762017

2008

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE 14-3-3ζ is involved in the regulation of PI3K/Akt pathway which is closely associated with carcinogenesis. 29439255

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE PI(3)K-mediated activation of the cell survival kinase PKB/Akt, and negative regulation of PI(3)K signalling by the tumour suppressor PTEN (refs 3, 4) are key regulatory events in tumorigenesis. 10972292

2000

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K plays an important role in tumorigenesis. 16839745

2006

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K/PTEN signaling in tumorigenesis and angiogenesis. 17964232

2008

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K pathway activation may drive tumorigenesis in a subset of MCC and screening these tumors for PIK3CA mutations could help identify patients who may respond to treatment with PI3K pathway inhibitors. 22261808

2012

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K/AKT/mTOR pathway plays a key role in the tumorigenesis of many human cancers including prostate cancer. 22491797

2012

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K pathway activation may occur as part of primary tumorigenesis, or as an adaptive response (via molecular alterations or increased phosphorylation of pathway components) that may lead to resistance to anticancer therapies. 23551097

2013

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE PI3K pathway mutation is prominent in proximal colon cancers, with PIK3CA exon 20 and PTEN mutations associated with features of the sessile-serrated pathway (MSI-H/CIMP-H/BRAF(mut)), and PIK3CA exon 9 (and to a lesser extent exon 20) mutation associated with features of the traditional serrated pathway (CIMP-L/KRAS(mut)) of tumorigenesis. 23633456

2013

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis. 24449057

2014

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE PI3K pathway mutation is important to cervical carcinogenesis in Latin America. 26080840

2015

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K/AKT signaling pathway plays an important role in tumorigenesis and regulates critical cellular functions including survival, proliferation and metabolism. 26995633

2016

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE PI3K is activated in cancer and affects several aspects of oncogenesis. 28176240

2017

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K/AKT/mTOR signaling pathway plays a crucial role in tumorigenesis and development. 29424922

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K/Akt/mTOR pathway is crucial for carcinogenesis and its inhibitors have made a great progress in cancer treatment. 29625382

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis. 29769245

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K-directed therapeutic interference showed that MLS cell proliferation and viability significantly depended on PI3K-mediated signals <i>in vitro</i> and <i>in vivo</i> Our preclinical study underlines the elementary role of PI3K/Akt signals in MLS tumorigenesis and provides a molecularly based rationale for a PI3K-targeted therapeutic approach which may be particularly effective in the subgroup of tumors carrying activating genetic alterations in PI3K/Akt signaling components. 30787173

2019

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K/Akt/mTOR signalling is an important event in colorectal carcinogenesis. 31215384

2019

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K/AKT is an imperative pathway involved in theproliferation and tumorigenesis of cancer cells and herein it was found that Scopoletin could inhibit this pathway. 31424653

2020

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE A model linking the main tumorigenesis (Wnt/TGF-beta-BMP/LKB-1/PI3K-AKT) pathways and a strategy for gene testing are proposed. 18774731

2009

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. 24244612

2013

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Aberrant activation and mutation status of proteins in the phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and the mitogen activated protein kinase (MAPK) signaling pathways have been linked to tumorigenesis in various tumors including urothelial carcinoma (UC). 22110663

2011