Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Risk-reducing salpingo-oophorectomy (RRSO) is recommended for BRCA1/2 mutation carriers because of their increased risk of ovarian carcinoma. 29315498

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Women with an existing breast carcinoma diagnosis who are found to carry a BRCA1/2 mutation have a substantial risk of developing both a contralateral breast carcinoma and ovarian carcinoma. 11900216

2002

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE One mutation and three rare variants were identified in four women with no family history of breast or ovarian carcinoma whereas all women with affected first-degree relatives did not harbor BRCA1 mutations. 10951344

2000

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Germ-line mutations in the BRCA1 and BRCA2 genes confer a predisposition to breast as well as ovarian carcinoma. 9661879

1998

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE BRCA1 5382insC mutation in sporadic and familial breast and ovarian carcinoma in Scotland. 9155062

1997

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE It is not yet known how frequently somatic BRCA1 mutations predispose to breast and ovarian carcinoma in the general female population. 8173065

1993

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. 28882436

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE To compare BRCA1 mutations in papillary serous carcinoma of the peritoneum and papillary serous ovarian carcinoma. 9764635

1998

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Aberrant Promoter Hypermethylation of RASSF1a and BRCA1 in Circulating Cell-Free Tumor DNA Serves as a Biomarker of Ovarian Carcinoma. 31653147

2019

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 AlteredExpression BEFREE Reduced BRCA1 gene expression is common in the sporadic form of ovarian carcinoma. 23339184

2013

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Alteration of expression of the tumor suppressor gene BRCA-1 has been widely studied in breast and ovarian carcinoma. 30446260

2019

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Eligible patients are premenopausal BRCA1/2 mutation carriers after completing childbearing without (a history of) ovarian carcinoma. 26286255

2015

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE At the time of salpingo-oophorectomy, five of 58 BRCA1 carriers (8.6%) were diagnosed with an occult carcinoma: two fallopian tube carcinomas, two ovarian carcinomas and one case was defined as a fallopian tube/ovarian carcinoma. 15083174

2004

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE We propagated a novel BRCA1-null human ovarian cancer cell line UWB1.289 from a tumor of papillary serous histology, the most common form of ovarian carcinoma. 17259345

2007

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE BRCA1/2 pathogenic (P) and likely pathogenic (LP) germline variants are frequent among patients with ovarian carcinoma. 30606148

2019

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE The similar frequency distribution of BRCA1/2 mutations in PPC and OvC observed in the present study indicates that these mutations may predispose to PPC as well and that this neoplasm is part of the hereditary breast-ovarian cancer syndrome. 12504628

2003

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE BRCA2 mutations were less common than BRCA1 mutations in families with any history of ovarian carcinoma. 10717622

2000

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE This study shows that BRCA1 IHC is well correlated with molecular events in ovarian carcinoma. 23232854

2013

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE A high proportion of young women with invasive OC have mutations in BRCA1, and a smaller fraction have mutations in other known OC genes. 26718727

2016

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE BRCA-1 and BRCA-2 are tumor suppressor genes in familial breast-ovarian carcinoma syndrome. 11550149

2001

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53. 10880552

2000

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Multiple mechanisms cause nearly universal dysfunction of BRCA1 and/or BRCA2 in hereditary and sporadic ovarian carcinoma. 12237285

2002

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Potent immunogenicity in BRCA1-mutated patients with high-grade serous ovarian carcinoma. 29855141

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE The identification of germ-line mutations in 2 genes (BRCA1 and BRCA2) responsible for the majority of hereditary ovarian cancers has led an increasing number of women carriers of these mutations to undergo prophylactic oophorectomy (PO) to reduce their risk of subsequent ovarian carcinoma. 17001151

2006

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Here, we show that the p53-related gene p73, encoding a proapoptotic protein that is linked to chemosensitivity in many settings, is upregulated through a novel epigenetic mechanism in both human and murine models of BRCA1-associated ovarian carcinoma. 20807817

2010