Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE Overall, the methylation pattern correlated with the major biological (ZAP-70 and CD38), and molecular (IGHV mutation) markers, distinguishing CLL cases according to IGHV mutational status. 24347044

2014

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE The RPPA investigation and its validation, identified 3 series of proteins: 1) molecules whose expression levels reached statistically significant differences in CLL vs. healthy controls (HSP70, Smac/DIABLO, cleaved PARP, and cleaved caspase-6); 2) proteins with a positive trend of difference in CLL vs. healthy controls (HS1, γ-tubulin, PKC α/β-II Thr-638/641, p38 MAPK Thr-180/Tyr-182, NF-κB Ser-536, Bcl2 Ser-70 and Src Tyr-527); and 3) molecules differentially expressed in patients with IGHV mutations vs. those without mutations (ZAP70, PKC-ζλ, Thr-410/403, and CD45). 27312846

2016

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 AlteredExpression BEFREE TAp63 mRNA levels were higher in CLL with unmutated IGHV. 24117128

2013

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE These data suggest that del(13q) conveys an indolent course only in patients with IGHV-mutated CLL. 21851216

2011

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 AlteredExpression BEFREE Most investigated drugs demonstrated similar activity in CLL cells from patients with unmutated and mutated IGHV genes as well as in CLL cells vs. PBMC. 19245531

2009

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker BEFREE Deletion 11q22 and IGHV status predict PFS in previously untreated CLL patients. 31054420

2019

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE Chromosomal aberrations, IGHV and TP53 mutation status are well-established and essential to discriminate between a more indolent course of disease and a high-risk CLL, which requires an alternative treatment regimen. 26890126

2016

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker BEFREE The mutational status of the immunoglobulin heavy chain variable (IGHV) genes identifies two subsets of CLL with different outcomes. 23531595

2013

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE We retrospectively analyzed 463 patients with CLL with available immunoglobulin heavy-chain variable (IGHV) gene status and B-cell receptor (BCR) configuration [heavy-chain complementary-determining region 3 (HCDR3)], of whom thirty-six developed ITP, according to previously defined criteria. 22322667

2012

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker BEFREE The reasons for this difference are still unclear, but it has been noted that particular IGHV genes associate with U-CLL vs M-CLL. 28125682

2017

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker BEFREE Further research of specific IGHV gene usage and subsets of stereotyped BCRs in CLL may be helpful in more precise prediction of CLL prognosis in individual patients. 21503826

2012

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE Mutations in known CLL drivers are seen in only 33% of this cohort, and associated with normal cytogenetics and unmutated IGHV. 26638776

2015

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 AlteredExpression BEFREE In the present series, 201 (21.9%) of 916 patients with CLL expressed IGHV genes that belonged to 1 of 48 different subsets of sequences with stereotyped heavy chain (H) CDR3. 16985177

2007

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker BEFREE Samples were split into CLL-Training (n=102) and CLL-Validation (n=114) sets, and an independent supervised analysis for IGHV mutational status was performed considering all genes with gene expression equal or above that of ZAP-70. 26038121

2015

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE The aim of this work was to characterize hTERT splice variants in CLL in relation to disease activity, clinical stage, immunoglobulin heavy chain variable (IGHV) genes mutational status, and TL. 23548418

2013

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 AlteredExpression BEFREE Although the presence of an unmutated IgV(H) gene is strongly associated with the expression of ZAP-70, ZAP-70 is a stronger predictor of the need for treatment in B-cell CLL. 15329427

2004

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE A marked increase of DEK mRNA expression was observed in the CLL patients with unmutated immunoglobulin heavy chain variable (IGHV) gene (p = 0.025), CD38-positive (p = 0.047), del(17p13) (p = 0.006). 23052131

2012

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker BEFREE IgHV1-69 is one of the most frequently rearranged IgHV genes in CLL and the majority of IgHV1-69 cases lack somatic hypermutation and display poor prognosis. 18398745

2008

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE Identical IGHV-D-J gene rearrangement may precede the clinical onset of chronic lymphocytic leukemia by several years. 20872553

2010

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE The immunoglobulin heavy chain variable (IGHV) gene mutational status represents a major prognostic marker in chronic lymphocytic leukemia (CLL). 23450508

2013

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE Moreover, discordant ISO(+)TNK(-) cases had a IgV(H) gene mutation profile similar to that of concordantly positive cases and different from ZAP-70 concordantly negative B-CLL. 16906587

2006

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker BEFREE The existence of subsets that comprise given IGKV-J/IGLV-J domains associated with IGHV-D-J domains that display homologous CDR3 provides further evidence for the role of antigen in CLL pathogenesis. 16076869

2005

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation BEFREE The expression of several genes correlates closely with the IGHV mutational status and could be used to assess prognosis in CLL. 27185377

2017

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 AlteredExpression BEFREE It was showed that LPL expression correlates with IgVH mutational status and other clinical or laboratory prognostic factors, and might be applied for the assessment of prognosis in patients with CLL. 18616755

2009

Entrez Id: 28309
Gene Symbol: IGHV3OR16-7
IGHV3OR16-7
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker BEFREE We applied high-resolution methylation microarrays (27,578 CpG sites) to assess the global DNA methylation profiles in 20 MCL (10 each with high/low proliferation signature) and 30 CLL (15 poor-prognostic IGHV unmutated subset #1 and 15 good-prognostic IGHV mutated subset #4) samples. 22374828

2012