Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE We determined MYC gene numerical aberrations and protein expression at different stages of penile squamous cell carcinoma carcinogenesis. 22999547

2012

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 PosttranslationalModification BEFREE These results suggest that MYC hijacks a major epigenetic pathway - H3K4 methylation - to facilitate its molecular activity in target binding and to coordinate its oncogenic program for efficient tumorigenesis, meanwhile creating "epigenetic vulnerability." 29870403

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MLV lacking the IN TP via an altered open reading frame was used to infect tumorigenesis mouse model (MYC/Runx2) animals to observe integration patterns and phenotypic effects, but viral passage resulted in the restoration of the IN TP through small deletions. 31815961

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Given MYC's consolidated role in oncogenesis, cell competition is supposed to be relevant to cancer, but its significance in human malignant contexts is largely uncharacterised. 28974715

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE The c-myc gene is frequently overexpressed in human breast cancer and its target genes are involved in tumorigenesis. 20144848

2010

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The importance of miRNAs in MYC-driven tumorigenesis has been enlightened by studying cell line and murine lymphoma models with conditional expression of MYC. 19197161

2009

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis. 31442917

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE This "FDG signature" predicted FDG uptake in breast cancer cell lines and overlapped with established gene expression signatures for the "basal-like" breast cancer subtype and MYC-induced tumorigenesis in mice. 21646475

2011

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE This mouse model should significantly accelerate understanding and treatment of the most aggressive form of medulloblastoma and infers distinct roles for MYC and MYCN in tumorigenesis. 22340591

2012

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MYC had been presumed to contribute to tumorigenesis through tumor cell-intrinsic influences. 29514782

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Further, we analyzed our model's predictions to better understand the molecular processes underlying synergy and discovered that key regulators of tumorigenesis such as TNFA and BRAF are often targets in synergistic interactions, while MYC is often duplicated. 31222109

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Neoplastic transformation and tumorigenesis by the human protooncogene MYC. 2156260

1990

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. 30415952

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE The expression of a 2.7-kb transcript, of c-sis and overexpression of c-myc gene may play some role in the carcinogenesis of esophageal carcinoma. 8131089

1994

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Different strategies for pharmacological interference with MYC- or RAF-induced tumorigenesis are being developed and several RAF kinase inhibitors are already in clinical use. 28466200

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE We conclude that c-MYC overexpression sensitizes cells to NF-kappaB-induced apoptosis, and persistent inactivity of NF-kappaB signaling is a prerequisite for MYC-mediated tumorigenesis. 19628709

2009

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MYC genes have both essential roles during normal development and exert oncogenic functions during tumorigenesis. 27748763

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE MiR-9 promotes tumorigenesis and angiogenesis and is activated by MYC and OCT4 in human glioma. 30795814

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE However, the critical effectors of MYC in tumorigenesis remain largely unknown. 25970242

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In this perspective, the major MYC cofactors that regulate the various transcriptional activities of MYC, including canonical and noncanonical transactivation and transcriptional repression, will be reviewed and a model of how these transcriptional mechanisms control MYC-mediated proliferation, apoptosis, and tumorigenesis will be presented. 24939054

2014

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Thus, in addition to directly targeting protein-coding genes, MYC modulates genes important to oncogenesis via deregulation of miRNAs, thereby vitally contributing to MYC-induced lymphomagenesis. 18713946

2008

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE In addition overexpression of c-MYC in transgenic mouse models results in prostatic carcinogenesis. 15937962

2005

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These results unveil that RASSF7 and c-Myc are functionally linked in the control of tumorigenesis and open up potential therapeutic avenues for targeting the "undruggable" c-Myc protein in a subset of human cancers. 30139745

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC). 29464015

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Oncogenic protein MTBP interacts with MYC to promote tumorigenesis. 24786788

2014