Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 GeneticVariation BEFREE 5-AzaCdR treatment increased the invasiveness of non-invasive breast cancer cell lines MCF-7 cells and ZR-75-1 and dramatically induced pro-metastatic genes; Urokinase plasminogen activator (uPA), matrix metalloproteinase 2 (MMP2), metastasis-associated gene (H-MTS1; S100A4) and C-X-C chemokine receptor 4 (CXCR4). 20980350

2011

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Metastasis-inducing S100A4 protein is associated with the disease activity of rheumatoid arthritis. 19828600

2009

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Metastasis-associated S100A4 is a specific amine donor and an activity-independent binding partner of transglutaminase-2. 26487698

2016

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 is considered functionally involved in metastasis and invasiveness of rodent and human mammary tumors. 10737717

2000

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 is involved in tumor progression, cell migration and metastasis. 12445462

2002

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE S100A4 expression with reduced E-cadherin expression predicts distant metastasis of human malignant melanoma cell lines in the NOD/SCID/gammaCnull (NOG) mouse model. 16077966

2005

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE S100A4 is frequently expressed in tumor and host cells in OC, with upregulated stromal expression in solid metastases. 19194111

2009

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 appears important for cancer metastasis and its overexpression is common in a variety of human malignancies, but its status in epidermal cancers remains lesser known. 19703228

2009

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE S100A4 protein belongs to the S100 subfamily, which has grown to be one of the large subfamilies of the EF-hand Ca(2+)-binding proteins, and overexpression of S100A4 is suggested to associate with cell proliferation, invasion, and metastasis. 19799859

2009

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 and metastasis: a small actor playing many roles. 20019188

2010

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4, a calcium-binding protein, is implicated in promoting metastasis formation in colon cancer. 21685359

2011

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4-induced cellular processes associated with metastasis formation, such as cell migration and invasion, were inhibited by calcimycin in an S100A4-specific manner. 21795396

2011

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 and VEGF are associated with tumour invasion and metastasis, and may be useful prognostic markers in patients with CCRCC. 22613408

2012

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 is a major prometastatic protein involved in tumor invasion and metastasis which precise role in pancreatic cancer has not been fully investigated. 23026527

2012

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4, a member of the Ca(2+) dependent S100 protein family, is reported to associate with metastasis through regulation of the motility and invasiveness of cancer cells. 23085231

2012

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Metastasin is a Ca(2+)-binding protein associated with tumor metastasis. 23483190

2013

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 is a well established marker and mediator of metastatic disease, but the exact mechanisms responsible for the metastasis promoting effects are less well defined. 23832737

2013

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 is a known mediator of EMT, leading to metastasis and EMT has been proposed as a potential source of cancer-associated fibroblastic cells in solid tumors. 24037664

2013

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE S100A4 mRNA expression was significantly correlated with tumor size, vascular invasion, node metastasis and tumor stage. 24706305

2014

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE S100A4, a small calcium-binding protein belonging to the S100 protein family, is commonly overexpressed in a variety of tumor types and is widely accepted to associate with metastasis by regulating the motility and invasiveness of cancer cells. 24732359

2014

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 can be regarded as a negative prognostic biomarker or a metastasis-risk factor of human c-SCCs. 25171474

2014

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100 calcium binding protein A4 (S100A4) and cysteine-rich angiogenic inducer 61 (CYR61) play important roles in epithelial-mesenchymal-transition (EMT), invasion and metastasis by promoting cancer cell motility. 27098123

2016

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 protein is a key player in promoting metastasis and sequestrating the effect of tumor-suppressor protein p53. 28244731

2017

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 is a Ca<sup>2+</sup>-binding protein that performs an important role in metastasis. 29251175

2018

Entrez Id: 6275
Gene Symbol: S100A4
S100A4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE S100A4 plays important roles in tumor metastasis, but its role in regulating autophagy has not been well characterized. 29449540

2018