Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE COX-1 and COX-2 messenger RNA (mRNA) levels were determined by Northern blot analysis of poly(A)+ RNA isolated from human colorectal cancers, adenomas, and accompanying normal mucosa. 7926468

1994

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE The aim of this study was to compare the content of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in colorectal cancers with the content in normal colonic specimens. 8566864

1996

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Gene expression of cyclooxygenase-2, group II and cytosolic phospholipase A2 in human colorectal cancer. 9858896

1998

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Overexpression of cyclooxygenase-2 (COX-2) has been implicated in carcinogenesis of human colorectal cancer which is one of the leading types of cancer in Western countries. 9703885

1998

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Cyclooxygenase-2-selective antagonists do not inhibit growth of colorectal carcinoma cell lines. 9464487

1998

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Here, we have studied the relationship between the COX-2 mRNA levels and pathological characteristics in 43 primary colorectal carcinomas. 9809985

1998

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE These observations indicate that colorectal cancers with molecular and phenotypic characteristics of defective DNA mismatch repair express lower levels of COX-2. 9850081

1998

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Regular administration of non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the incidence of colorectal cancer by targeting cyclo-oxygenase-2 (Cox-2), a key enzyme in arachidonic acid metabolism. 10398082

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Chemoprevention of colorectal cancer through inhibition of cyclooxygenase-2. 10528897

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE We analyzed and compared expression of the inducible COX-2 isoform in colorectal neoplasms from patients with hereditary nonpolyposis colorectal cancer (HNPCC), familial adenomatous polyposis (FAP), and sporadic CRC. 10419916

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Evidence indicates that cyclooxygenase-2 (COX-2) is induced and at elevated levels in human colorectal cancers and in the polyps of mouse FAP models. 10545404

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Both matrilysin and Cox-2 expression was increased in the mouse models and in the human colorectal cancers; however, immunohistochemistry and in situ hybridization indicated that their localization within the tumors was different. 10204802

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Analysis of PPARdelta mRNA in matched normal and tumor samples revealed that expression of PPARdelta, similar to COX-2, is up-regulated in colorectal carcinomas. 11087869

2000

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE These data provide the first rational basis for overexpression of COX-2 in CRC and offer an additional potential target for managing this disease. 10766162

2000

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Cyclooxygenase-2 (COX-2) is not normally expressed in the human large intestine, but its levels are increased in the majority of human colorectal carcinomas. 10930401

2000

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Meloxicam (preferential COX-2 inhibitor) inhibits the growth of COX-2 positive and COX-1 negative colorectal cancer cells. 11062695

2000

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Since COX-2 inhibitors have been demonstrated to interfere with tumorigenesis and apoptosis, COX-2 and its gene product may be attractive targets for therapeutic and chemoprotective strategies in colorectal cancer patients. 11469677

2001

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Up-regulation of cyclooxygenase-2 (COX-2) protein is frequently found in human colorectal cancer (CRC). 11396184

2001

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE To further elucidate the mechanism responsible for increased levels of PGE(2) in colorectal tumors, we determined the amounts of mPGES and COX-2 in 18 paired samples (tumor and adjacent normal) of colorectal cancer. 11751489

2001

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker CTD_human Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugs show altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA expression levels. 11375891

2001

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE The aim of this study was to determine whether COX-2 expression and PGE(2) production correlate with microvessel density, vascular endothelial growth factor (VEGF) expression, and tumor metastasis in human colorectal cancer. 11729113

2001

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE The expression of cyclooxygenase-2 was found to be up-regulated in colorectal carcinoma and other cancers. 11342898

2001

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE These results suggest that cyclooxygenase-2 overexpression in colorectal cancer is associated with non-polypoid growth. 12110643

2002

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE The inducible cyclooxygenase-2 (COX-2) gene regulates prostaglandin biosynthesis,is up-regulated in colorectal cancers, and can influence apoptotic susceptibility. 12208739

2002