Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation CLINVAR Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome. 22658544

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation CLINVAR High frequency of mutations of the PIK3CA gene in human cancers. 15016963

2004

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation CLINVAR PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. 15608678

2005

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 Biomarker BEFREE Integrated analysis of public data from gastric tumors revealed frequent (10 - 20 %) amplification of the genes NFKBIE, PTK2, and PIK3CA, each of which resides in an ERBB2-derived subpathway network. 26955870

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation CLINVAR De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. 22729224

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 AlteredExpression LHGDN Activation of the PI3K signalling pathway in gastric cancer may be achieved through up-regulation or mutation of PIK3CA, in which the latter may be a consequence of mismatch repair deficiency. 15784156

2005

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 AlteredExpression BEFREE Mutually exclusive alterations of PTEN and PIK3CA also suggest that mutations of either gene could activate the PI3-kinase/AKT signaling pathway, which is directly linked to the malignant progression of gastric tumor cells. 12569555

2003

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation CLINVAR Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA. 22729222

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation CLINVAR Mutation of the PIK3CA gene in ovarian and breast cancer. 15520168

2004

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 Biomarker BEFREE These observations suggest that PI3K can regulate cell cycle progression and cell proliferation in human gastric tumor cells via Rb-mediated pathway, and that this effect of PI3K is mediated through a direct association with Rb via the N-terminal end of its p55 kDa regulatory subunits and modulating Rb-E2F interactions. 15809724

2005

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation CLINVAR De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly. 22729223

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation CGI

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 Biomarker HPO

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation CLINVAR Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. 17673550

2007

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 Biomarker CTD_human Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. 22484628

2012