Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These PIK3CA and PIK3R1 impactful mutations exhibit a mutually exclusive pattern, leading to oncogenesis and hyperactivity of PI3K pathway. 29636477

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The PI3K/Akt and MAP kinase pathways play important roles in a variety of normal cellular processes and tumorigenesis. 25640606

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Functional screening of FGFR4-driven tumorigenesis identifies PI3K/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma. 29487419

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These findings show that mutated PI3K may be involved in the NPC tumorigenesis but does not affect patient's prognosis, suggesting that PI3K is a potential target in NPC for targeted therapeutics using specific kinase inhibitors. 19012001

2009

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Some in vitro studies have shown that EGFR and PI3K-Akt pathway play an important role in the carcinogenesis of bile duct carcinoma. 27020207

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE We hypothesized that aberrant methylation and hence altered expression of certain unknown important genes induced by the genetically activated PI3K pathway signaling is a major epigenetic mechanism in human tumorigenesis. 26472282

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Aberrations of signal transducers in PI3K/Akt pathway have been found in many human cancers, and may play a critical role in carcinogenesis. 19628421

2009

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Computational analysis indicated that miR-296-3p targeted PTEN, which regulates the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and PTEN is involved in the carcinogenesis of SCC. miR-296-3p directly regulated PTEN expression in head and neck cancer cells, with PTEN protein levels decreased in 4/19 the SCCs (21.0%), as compared with those in the IPs (76.4%). 28693263

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The results revealed that the ERBB and PI3K-related pathways played important roles in the carcinogenesis of CCC, EC and MC; while deregulation of cell cycle was more predominant in SC. 27527159

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway plays a critical role in carcinogenesis and resistance to anticancer drugs. 29181056

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE 14-3-3ζ is involved in the regulation of PI3K/Akt pathway which is closely associated with carcinogenesis. 29439255

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE For the first time, a role for NDRG1 is established in regulating the key signaling pathways involved in oncogenesis (TGF-β, PI3K, and Ras pathways). 22462691

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The presence of the PIK3CA mutation and the wild-type KRAS, BRAF, CTNNB1 genes, and the intact PTEN expression in 3 sporadic CMV-PTCs may suggest the possible contribution of the PIK3CA mutation in its tumorigenesis. 26054797

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE It has been recently proposed that in this oncogenic charge-reversal mutation, the interactions between the protein catalytic and regulatory subunits are abrogated, resulting in loss of regulation and constitutive PI3Kα activity, which can lead to oncogenesis. 30341384

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The activation of the phosphoinositide-3-kinase (PI3K)/AKT Serine/Threonine Kinase 1 (AKT)/mechanistic target of Rapamycin (mTOR) pathway is important in cancer tumorigenesis, progression and chemotherapy resistance. 29456722

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K pathway activation may occur as part of primary tumorigenesis, or as an adaptive response (via molecular alterations or increased phosphorylation of pathway components) that may lead to resistance to anticancer therapies. 23551097

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K-directed therapeutic interference showed that MLS cell proliferation and viability significantly depended on PI3K-mediated signals <i>in vitro</i> and <i>in vivo</i> Our preclinical study underlines the elementary role of PI3K/Akt signals in MLS tumorigenesis and provides a molecularly based rationale for a PI3K-targeted therapeutic approach which may be particularly effective in the subgroup of tumors carrying activating genetic alterations in PI3K/Akt signaling components. 30787173

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE We concluded that 3,6-DHF upregulates miR-34a via inhibiting DNMT1 and hypermethylation, whereas downregulates miR-21 by modulating histone modification, and consequently suppresses the PI3K/Akt/mTOR signaling pathway in breast carcinogenesis. 25784176

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Mutations in p53 or in PTEN/PIK3CA are alternative pathways in ovarian carcinogenesis. 17258789

2007

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Our results demonstrate that miR-142-5p functions as a growth suppressive miRNA and plays an important role in inhibiting the tumorigenesis through targeting PIK3CA in non-small cell lung cancer. 29131028

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE We suggest that PIK3CA is significant in breast tumorigenesis serve as a prevalent mechanism contributes to the oncogenic activation pathway of PIK3CA in breast cancer. 24782652

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE Our results show that (1) the TSHR(M623) or (M632) cDNAs give rise to 3T3 clones presenting a fully neoplastic phenotype (growth in agar and nude mouse tumorigenesis); this phenotype was weaker in the cells transformed by the 632 cDNA; (2) suggest that the fully transformed phenotype of our 3T3 cells, may be the consequence of the additive effect of the activation of at least two different pathways: the cAMP pathway through G(alpha)s and the Ras dependent MAPK pathway through G(beta)gamma and PI3K and (3) show that the PI3K isoform playing a key role as an effector in the MAPK pathway activation in our 3T3-transformed cells is PI3Kgamma. 11039907

2000

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis. 24449057

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE MG53 is transcriptionally activated by the IRS-1/PI3K/AKT signal pathway, which is closely related with oncogenesis of several tumors. 30690890

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE In contrast, midkine (MK), a heparin-binding growth factor and cytokine, which induces carcinogenesis and chemoresistance, promotes the development and progression of many malignant tumours by increasing diverse cell functions such as cell proliferation, cell survival and antiapoptotic activities via mainly the activation of phosphatidyl inositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways. 31634770

2020