Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Here we present the results of a search for a region that exhibits linkage disequilibrium with the disorder, under the assumption that identification of such a region may provide an alternative method of narrowing down the location of WRN, the gene responsible for WS. 8037212

1994

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Recombination events were detected between WRN and the HRG and FGFR1 genes, excluding them as candidates for the WRN gene. 8325642

1993

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 CausalMutation CLINVAR The gene responsible for WS (known as WRN) was identified by positional cloning. 8602509

1996

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker CLINGEN The gene responsible for WS (known as WRN) was identified by positional cloning. 8602509

1996

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker GENOMICS_ENGLAND The gene responsible for WS (known as WRN) was identified by positional cloning. 8602509

1996

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker GENOMICS_ENGLAND The gene responsible for WS (known as WRN) was identified by positional cloning. 8602509

1996

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE The gene responsible for WS (known as WRN) was identified by positional cloning. 8602509

1996

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker CLINGEN Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. 8641691

1996

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE Analysis of these markers in Werner syndrome subjects demonstrates that the candidate WRN gene is in a region of linkage disequilibrium. 8812476

1996

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE The Saccharomyces cerevisiae SGS1 gene is homologous to Escherichia coli RecQ and the human BLM and WRN proteins that are defective in the cancer-prone disorder Bloom's syndrome and the premature aging disorder Werner's syndrome, respectively. 8913739

1996

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 CausalMutation CLINVAR Homozygous and compound heterozygous mutations at the Werner syndrome locus. 8968742

1996

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 CausalMutation CLINVAR Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. 9012406

1997

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE These results confirm that mutations in the WRN gene are responsible for WS. 9012406

1997

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker CLINGEN Analysis of helicase gene mutations in Japanese Werner's syndrome patients. 9048918

1997

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE The correlation between mutations in the Werner's syndrome (WRN) gene and the haplotypes of surrounding markers was studied in Japanese patients. 9225981

1997

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 CausalMutation CLINVAR Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population. 9225981

1997

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Mutations in WRN result in Werner's syndrome, a disease with symptoms resembling premature aging. 9271578

1997

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Second, the monitoring of the telomere length of both normal and WRN cell strains during the culture period suggests that the WRN gene mutation causes abnormal dynamics of the telomere: (1) a significant proportion of WRN cell strains showed drastic shortening or lengthening of telomere lengths during cell passages compared with normal cell strains, and (2) WRN cell strains terminated their life-span at a wide range of telomere length (between 3.5 and 18.5 Kbp), whereas normal cell strains terminated within a narrow telomere length range (between 5.5 and 9 Kbp). 9365237

1997

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Affected and unaffected members of a Caucasian family with Werner syndrome were analyzed for mutations in the recently described Werner syndrome (WRN) gene and for their relevance to phenotypic expression of chromosomal instability and x-ray hypersensitivity. 9450180

1998

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE BLM- and WRN-bearing yeasts provide new useful models to investigate human BS and WS diseases. 9671747

1998

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 PosttranslationalModification BEFREE The activity of the WRN promoter was dramatically reduced in cells from WS patients. 9671808

1998

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 AlteredExpression BEFREE Moreover, it is a homologue of the human Werner syndrome gene product WRN, a protein associated with premature ageing in humans. 9697700

1998

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 GeneticVariation BEFREE Our results suggest that the hypersensitivity to 4NQO and the extensive deletion mutations observed in the WS cell line are caused by a defect that is secondary to the WRN gene mutation, possibly a repair gene defect that controls the phenotypes of hypersensitivity to carcinogen(s) and/or the extensive deletion mutations. 9823331

1998

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE The association of an exonuclease with WRN distinguishes it from other RecQ homologs and raises the possibility that the distinct phenotypic characteristics of WS may be due in part to a defective exonuclease. 9852073

1998

Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
1.000 Biomarker BEFREE We prepared several monoclonal antibodies (mAbs) specific for the NH2- and COOH-terminal regions of the DNA helicase (WRN helicase) responsible for Werner's syndrome known as a premature aging disease. 9885239

1999