Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Our results suggest the existence of both a genetic and connubial effect on CEA, presumably due to a common environmental agent acting in concert with the degree of genetic predisposition to oncogenesis in this syndrome. 709527

1978

Entrez Id: 49
Gene Symbol: ACR
ACR
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.020 GeneticVariation BEFREE The results suggest that this phenotypic marker may be useful in identifying ACR gene carriers and in probing cellular controls of carcinogenesis. 7287208

1980

Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Not only the dose but the route of administration and the tissue in which the malignancy or toxicity develops are therefore very important in the interpretation of data from tumorigenesis or toxicity experiments involving P1-450 inducers such as polycyclic hydrocarbons. 7016519

1981

Entrez Id: 60
Gene Symbol: ACTB
ACTB
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Actin mutations in a human fibroblast model for carcinogenesis. 7074877

1982

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE If similar enhancers exist in humans they may lead to increased transcription of the translocated c-myc gene and thus contribute to oncogenesis in Burkitt lymphoma. 6419124

1984

Entrez Id: 404663
Gene Symbol: LINC01194
LINC01194
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Since we have mapped the low-oncogenic or nononcogenic Ad12 cyt mutants within the 19-kd tumor antigen-coding region, our results further indicate that the 19-kd tumor antigen also directly or indirectly plays an important role in tumorigenesis of Ad12. 6492253

1984

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These changes are probably the result of somatic mutations that occurred during and after translocation, and may contribute to oncogenesis by allowing synthesis of an altered c-myc gene product. 6419122

1984

Entrez Id: 4613
Gene Symbol: MYCN
MYCN
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE This finding suggests that N-myc gene may have a primary role in the tumorigenesis of retinoblastoma. 6728001

1984

Entrez Id: 100188830
Gene Symbol: AD12
AD12
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 Biomarker BEFREE Since we have mapped the low-oncogenic or nononcogenic Ad12 cyt mutants within the 19-kd tumor antigen-coding region, our results further indicate that the 19-kd tumor antigen also directly or indirectly plays an important role in tumorigenesis of Ad12. 6492253

1984

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE As the transfectants acquire an indefinite life-span and anchorage independence they became transplantable tumor cells and showed many phenotypic changes suggesting a pleiotropic mechanism for the role of Ha ras in human carcinogenesis. 3975607

1985

Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE However, high AHH induction in smokers implies an increased risk of smoking-induced carcinogenesis. 6335015

1985

Entrez Id: 1443
Gene Symbol: CSH2
CSH2
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.020 Biomarker BEFREE Linkage of human chorionic gonadotrophin and placental lactogen biosynthesis to trophoblast differentiation and tumorigenesis. 2991878

1985

Entrez Id: 1442
Gene Symbol: CSH1
CSH1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 Biomarker BEFREE Linkage of human chorionic gonadotrophin and placental lactogen biosynthesis to trophoblast differentiation and tumorigenesis. 2991878

1985

Entrez Id: 2217
Gene Symbol: FCGRT
FCGRT
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 Biomarker BEFREE Since this region of chromosome has been shown to be nonrandomly involved in a number of T cell neoplasias, this assignment raises a number of interesting questions as to the possible involvement of the T cell receptor alpha chain genes in tumorigenesis. 3872924

1985

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE This gene shares structural and sequence homologies with the epidermal growth factor receptor (erb-B oncogene) and members of the src family of oncogenes, suggesting that alterations in the insulin receptor, resulting from chromosomal translocation, could lead to a role in tumorigenesis. 3943110

1986

Entrez Id: 5820
Gene Symbol: PVT1
PVT1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The significance of these results with respect to the role of pvt-1 in tumorigenesis is discussed. 3024964

1986

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 PosttranslationalModification BEFREE These results suggest that rearrangement of the c-myc gene may play some role in tumorigenesis of giant cell carcinoma of the lung. 3093421

1986

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE This gene shares structural and sequence homologies with the epidermal growth factor receptor (erb-B oncogene) and members of the src family of oncogenes, suggesting that alterations in the insulin receptor, resulting from chromosomal translocation, could lead to a role in tumorigenesis. 3943110

1986

Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker BEFREE These results suggest a possible involvement of GAPDH itself or a GAPDH-related protein in lung tumorigenesis. 3089988

1986

Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These results suggest that loss or mutation of a gene on chromosome 22 may play an important role in tumorigenesis in MEN2A. 2889715

1987

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Different groups have shown that: 1) the global structure of the albumin and AFP genes does not change during the course of development and hepatic carcinogenesis; 2) modifications at the level of the methylation of certain specific cytosines could be associated with the variations in the transcription of these genes; 3) global or local (hypersensitive sites with DNase I) changes of chromatin conformation could be correlated to the potential or the overt activity of the transcription of these genes. 2445387

1987

Entrez Id: 213
Gene Symbol: ALB
ALB
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.040 GeneticVariation BEFREE Different groups have shown that: 1) the global structure of the albumin and AFP genes does not change during the course of development and hepatic carcinogenesis; 2) modifications at the level of the methylation of certain specific cytosines could be associated with the variations in the transcription of these genes; 3) global or local (hypersensitive sites with DNase I) changes of chromatin conformation could be correlated to the potential or the overt activity of the transcription of these genes. 2445387

1987

Entrez Id: 1773
Gene Symbol: DNASE1
DNASE1
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.030 GeneticVariation BEFREE Different groups have shown that: 1) the global structure of the albumin and AFP genes does not change during the course of development and hepatic carcinogenesis; 2) modifications at the level of the methylation of certain specific cytosines could be associated with the variations in the transcription of these genes; 3) global or local (hypersensitive sites with DNase I) changes of chromatin conformation could be correlated to the potential or the overt activity of the transcription of these genes. 2445387

1987

Entrez Id: 2526
Gene Symbol: FUT4
FUT4
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 Biomarker BEFREE These results demonstrate that the flat mucosa of patients with familial polyposis coli shows preneoplastic changes similar to those in the mucosa adjacent to carcinoma of sporadic cases, and that SSEA-1 is related to adenoma formation in the early stage of carcinogenesis in the colorectum. 2885160

1987

Entrez Id: 11222
Gene Symbol: MRPL3
MRPL3
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 AlteredExpression BEFREE Therefore, MRL3 overexpression seems to be a property of rapidly dividing cells and is not directly linked to oncogenesis. 2891103

1987