Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 81609
Gene Symbol: SNX27
SNX27
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE SNX27-retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis. 31820782

2020

Entrez Id: 83461
Gene Symbol: CDCA3
CDCA3
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE DNA hypomethylation promotes invasion and metastasis of gastric cancer cells by regulating the binding of SP1 to the CDCA3 promoter. 31211445

2020

Entrez Id: 6483
Gene Symbol: ST3GAL2
ST3GAL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 AlteredExpression BEFREE The study demonstrated significant role of elevated mRNA levels of ST3GAL2 and ST3GAL3 in disease progression and metastasis of oral carcinoma. 31747460

2020

Entrez Id: 6711
Gene Symbol: SPTBN1
SPTBN1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE This review summarizes the recent advances in the expression patterns of SPTBN1 in cancers, and in understanding the mechanisms by which SPTBN1 affects the occurrence, progression, and metastasis of cancer. 31206681

2020

Entrez Id: 440503
Gene Symbol: PLIN5
PLIN5
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE M1 is also characterized by the increased values of HIF-1α+ (factor 1.25), CD68+ (factor 1.4) and Plin5+ (factor 2.1) compared to M0 category in tumor tissues (p < 0.05). 31711773

2020

Entrez Id: 90668
Gene Symbol: CARMIL3
CARMIL3
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE Consistent with a predominantly cell-intrinsic mode of action, CARMIL3 is also crucial for tumor cell migration and invasion <i>in vitro</i>. 31694931

2020

Entrez Id: 285834
Gene Symbol: HCG22
HCG22
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE Long noncoding RNA HCG22 suppresses proliferation and metastasis of bladder cancer cells by regulation of PTBP1. 31304601

2020

Entrez Id: 100886964
Gene Symbol: PTCSC3
PTCSC3
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE Taken together, lncRNA PTCSC3 inhibited cell growth and metastasis via sponging miR-574-5p in cervical cancer. 31587336

2020

Entrez Id: 54477
Gene Symbol: PLEKHA5
PLEKHA5
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE The clinical relevance of PLEKHA5 dysregulation was further investigated in a cohort of matched cranial and extracranial melanoma metastases. 31769872

2020

Entrez Id: 100422909
Gene Symbol: MIR4295
MIR4295
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE As reported, miR-4295 promotes cell growth and metastasis in a lot of cancers. 31118494

2020

Entrez Id: 3632
Gene Symbol: INPP5A
INPP5A
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 AlteredExpression BEFREE We conducted a multicenter, single-institutional, retrospective cohort study within the Mayo Clinic Health System on the use of immunohistochemical staining to examine cSCC INPP5A protein expression in primary tumors and recurrent and metastatic disease. 31437542

2020

Entrez Id: 724102
Gene Symbol: SNHG4
SNHG4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE SNHG4 promoted ZIC5-mediated growth and metastasis through modulating miR-377. 31608997

2020

Entrez Id: 2444
Gene Symbol: FRK
FRK
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE FRK plays an oncogenic role in lung cancer cells via a novel regulation mechanism of enhancing the stemness of H1299 cells by inducing metabolism reprogramming, which finally promotes EMT and metastasis. 31251822

2020

Entrez Id: 6844
Gene Symbol: VAMP2
VAMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE In this study, we analyzed the relative expression of the STX1A and VAMP2 (SYB2) for their possible association in the progression and metastasis of bladder cancer. 30672978

2020

Entrez Id: 100874365
Gene Symbol: HOXC-AS3
HOXC-AS3
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE A Novel lncRNA HOXC-AS3 Acts as a miR-3922-5p Sponge to Promote Breast Cancer Metastasis. 31797701

2020

Entrez Id: 56651
Gene Symbol: LINC00470
LINC00470
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 AlteredExpression BEFREE In this study, our findings showed that LINC00470 was significantly upregulated in GC tissues and cell lines, and correlated with distant metastasis, TNM stage and poor prognosis. 31711642

2020

Entrez Id: 284836
Gene Symbol: LINC00319
LINC00319
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE Next, SGC-7901 cells presenting with the lowest LINC00319 expression and the highest <i>miR-335-5p</i> expression were transfected with LINC00319, <i>miR-335-5p</i> inhibitor or <i>ADCY3</i> vector to examine their roles in growth and metastasis of GC cells, which was further ascertained by <i>in vivo</i> experiments. 31433213

2020

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE We provide evidence that LRRK2 was an independent prognostic factor for ICC in humans by participating in the proliferation and metastasis of ICC cells. 31489563

2020

Entrez Id: 6608
Gene Symbol: SMO
SMO
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 AlteredExpression BEFREE In HNSCC patients, coexpression of GLI1 and SMO in primary tumors correlated with metastasis. 31408253

2020

Entrez Id: 22883
Gene Symbol: CLSTN1
CLSTN1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE To systematically review the literature on the prognostic value of lymphovascular invasion (LVI) and embryonal carcinoma (EC) for occult metastatic disease in CS I NSGCT. 31797520

2020

Entrez Id: 58504
Gene Symbol: ARHGAP22
ARHGAP22
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 GeneticVariation BEFREE We identified several methylation changes that can have role during melanoma progression, including hypermethylation of the promoter regions of the ARHGAP22 and NAV2 genes that are commonly altered in locally invasive primary melanomas as well as during metastasis. 31602702

2020

Entrez Id: 64374
Gene Symbol: SIL1
SIL1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE In this study, we aimed to investigate the effect of SIL1 on the proliferation, apoptosis, and metastasis of human breast cancer. 31791191

2020

Entrez Id: 3192
Gene Symbol: HNRNPU
HNRNPU
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE Furthermore, we will focus on the contradictory functions of E-cadherin and p120 in the different phases of tumor progression, from carcinoma in situ up to the formation of distant metastasis. 31369816

2020

Entrez Id: 101929441
Gene Symbol: ERLNC1
ERLNC1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE A series of in vitro and in vivo assays were performed to elucidate the roles and mechanism of TC0101441 in EOC metastasis. 31577838

2020

Entrez Id: 4899
Gene Symbol: NRF1
NRF1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker BEFREE The following clusters were found in the dendrogram: Nrf2 and p21 with ATP5B and GADPH in all the tissues and with NRF1 in all except the tumor tissues with metastasis; Bach1 with ATP5B and GAPDH in the tumor tissues; Keap1 with p62 in all the tissues, with LC3 in the tumor tissues and with NRF1 and HO1 in the tumor tissues with metastasis. 31796664

2020