×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Cetuximab treatment for metastatic colorectal cancer with KRAS p.G13D mutations improves progression-free survival.
26623049
2015
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model.
24558511
2014
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer.
23325582
2013
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab.
23182985
2013
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas.
22392911
2012
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.
22722830
2012
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab.
22734028
2012
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.
21228335
2011
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
GeneticVariation
CLINVAR
Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations.
21398618
2011
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations.
21398618
2011
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab.
20978259
2010
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study.
20921465
2010
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.
20921462
2010
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.
19679400
2009
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells.
19881948
2009
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer.
19114683
2009
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.
18316791
2008
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.
16618717
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma.
16361624
2005