Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Long-term treatment with T22 peptide (a CXCR4/SDF-1 inhibitor) and YY1 silencing can reduce in vivo systemic neoangiogenesis (P < 0.01 and P < 0.05 vs. control, respectively) during metastasis. 20660740

2010

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 GeneticVariation BEFREE Our in vitro and in vivo data strongly indicate that pVHL coordinately regulates expression of metastasis-associated genes CXCR4/CXCL12 and MMP2/MMP9 but the exact molecular mechanism of this regulation remains to be determined. 18189328

2008

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Importantly, the involvement of CXCR4 in cancer metastasis and WHIM syndrome appears to be due to dysregulation of the receptor leading to enhanced signaling. 17169327

2007

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Promotion of metastasis in response to miR-224 downregulation was associated with derepression of the stroma-associated RKIP target genes, CXCR4, MMP1, and OPN, which are involved in breast tumor metastasis to the bone. 22809510

2012

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Another factor explaining the osteotropism of CSCs is their ability to recognize chemokine gradients toward BM, through the CXCL12-CXCR4 axis, also known to be involved in tumor metastasis to other organs. 29461491

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE SEMA3F(high) /CXCR4(low) patients showed the lowest frequency of lymph node and distant metastasis and the longest survival. 25866254

2015

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE In clinical specimens, CXCR4 and phospho-p38 were widely overexpressed, and the levels increased with the progression from locoregional to metastatic tumors in NPC tissues. 24170200

2014

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Clinically, high levels of CXCR4 always correlated with metastasis and poor prognosis of CRC patients. 26745593

2017

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE We found particularly high expression of CXCR4 on adrenocortical cancer (ACC) metastases. 29088715

2017

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Our data showed down-regulation of CXCR4 expression using siRNA against CXCR4 could significantly reduce the enhanced metastasis of 95D cells induced by CpG ODN both in vitro and in vivo. 19302975

2009

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Mechanistically, we demonstrated that CXCL12/CXCR4 activated the ERK1/2 pathway and thereby ultimately maintained the characteristics of high-level invasion and metastasis of esophageal cancer stem cells. 28193907

2017

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Therefore, identification of nutritional factors which are able to inhibit CXCR4 is important for protection from environmental arsenic-induced carcinogenesis and for abolishing metastasis of malignantly transformed cells. 23743303

2013

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Expression of CXCR4 in cancers has been correlated with poor prognosis and increased metastasis. 21347799

2012

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Moreover, impairment of HIC1 expression in PCa cells induced their migration and metastasis through EMT, by enhancing expression of Slug and CXCR4, both of which are critical to PCa metastasis; the CXCL12-CXCR4 axis promotes EMT by activating the extracellular signal-regulated kinase (ERK) 1/2 pathway. 28466555

2017

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Similarly, CXCR4/SDF1α signalling correlates with ovarian cancer progression and metastasis. 26235278

2015

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Stromal cell-derived factor-1 (SDF-1 or CXCL12) and CXCR4 are key elements in the metastasis of prostate cancer cells to bone--but the mechanisms as to how it localizes to the marrow remains unclear. 17034033

2007

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE CXCL12/CXCR4 plays an important role in metastasis of gastric carcinoma. 22337890

2012

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Additionally, we found that CAFs could secrete stromal cell-derived factor-1 (SDF-1) and promote CRC cell metastasis in distant organs via the SDF-1/C-X-C chemokine receptor type 4 (CXCR4) axis. 30355650

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE The invasion and metastasis are regulated by multiple factors including CXCR4 chemokine receptor and multiple microRNAs. 26855082

2016

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Our goal was to dissect the contributions of CXCR4 and CXCR7 to the different steps of metastasis - in vivo invasion, intravasation and metastasis formation. 22152016

2011

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Silencing of CXCR4 by RNA interference inhibits cell growth and metastasis in human renal cancer cells. 22972438

2012

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Indeed, the migration toward SDF-1 (stromal cell-derived factor 1) of tumor cells bearing CXCR4 [chemokine (C-X-C motif) receptor 4] has been implicated in the lymphatic and organ-specific metastasis of various human malignancies. 21934106

2011

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE To evaluate the expression of C-X-C motif chemokine receptor 4 (CXCR4) and its signaling cascades, which were previously identified as a key factor for cancer cell progression and metastasis, in cholangiocarcinoma cell lines. 17461449

2007

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Previous studies found apoptosis of osteosarcoma cells was essential for an effective manner to improve the progress of osteosarcoma, and CXCR4 has been demonstrated to be relevant with various tumor progress and metastasis. 29734183

2018

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Downregulation of the CXCR4/CXCL12 axis thus reduces cancer growth and metastasis. 25960214

2015