Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 AlteredExpression BEFREE <b>Conclusions:</b> These results indicate that G9a-induced and p53-dependent epigenetic programing stimulates the growth of colon cancer, which also suggests that G9a inhibitors that restore p53 activity are promising therapeutic agents for treating colon cancer, especially for CRC expressing wild-type p53. 29774081

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE Wild-type and mutant p53 differentially modulate miR-124/iASPP feedback following pohotodynamic therapy in human colon cancer cell line. 29022915

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker BEFREE BTK inhibitors synergise with 5-FU to treat drug-resistant TP53-null colon cancers. 31518438

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker BEFREE Here, enterolacton, S-equol and urolithin A as representatives of metabolites of lignans, isoflavones and ellagitannins, respectively, were examined for their impact on HCT116 colon cancer cell growth, cooperativity with oxaliplatin and p53 dependency in vitro. 30418550

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker BEFREE Surface-Enhanced Raman Scattering (SERS) is used to differentiate two colon cancer cell line HCT 116, that is, to distinguish a TP53 gene knockout cell line (p53 -/-) from a wild type (p53 +/+). 30059864

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker BEFREE Mutant p53 in colon cancer. 30496442

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker BEFREE Since the tumor suppressor p53 is frequently involved in inducing apoptosis following DNA damage we investigated the effect of sanguinarine in wild type, p53-mutant and p53-null colon cancer cell lines. 18243168

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 AlteredExpression BEFREE To gain further insight into the effects of microvessel density and VEGF expression in colon cancer, their relation with tumour proliferation, ploidy status, and p53 expression was investigated in colon cancer. 16254106

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE Physical inactivity, large body mass index, cigarette smoking, using aspirin/nonsteroidal anti-inflammatory drugs, and other dietary factors appeared to be comparably associated with colon cancer in those with and without p53 mutations. 12050095

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE To demonstrate the program, the mutational spectra of single base substitutions in the p53 gene are compared in (i) bladder cancers from smokers and non-smokers, (ii) small-cell lung cancers, non-small-cell lung cancers and colon cancers and (iii) hepatocellular carcinomas from high- and low-aflatoxin exposure groups. p53 mutations differ in several important aspects from a typical mutational spectra experiment, where a homogeneous population of cells is treated with a specific mutagen and mutations at a specific locus are recovered by phenotypic selection. 7955067

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 AlteredExpression BEFREE Mutations spanning P53 exons 5-9 detected by non-isotopic RNAse cleavage assay and protein expression in human colon cancer. 11520564

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE The second form of genetic instability is characterized by the development of p53 gene abnormalities that result in gross aneuploidy and multiple structural chromosomal changes. p53/aneuploidy affects most colon cancers, breast cancers, and many other solid tumors. 9298807

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker BEFREE In addition to the risk for established LFS tumour types, TP53-positive individuals may also have an elevated risk for pancreatic and colon cancer. 20522432

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 AlteredExpression BEFREE IL1β increased malignant potential and regulated the expression of tumor suppressor (p53) and cell cycle regulatory genes (p21, p27, and cyclin E2) in human and mouse colon cancer cell lines. 24157941

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 AlteredExpression BEFREE Telomerase activity was relatively higher in most cancer tissues containing mutation(s) in KRAS or BRAF and/or TP53 compared to those without these hotspot mutations, suggesting that telomerase could become fully active at the late stage of colon cancer development. 25379018

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE In the present study, a large family with evidence of polyposis and colon cancer was screened for the mutations of the p53 gene and protein overexpression. 9732936

1998

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry. 26086041

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE Human colon cancer development is associated with the accumulation of mutations and deletions in the suppressor genes DCC, APC and p53 and mutations in the dominant oncogene K-ras, with loss of wild type alleles. 7970729

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker BEFREE The therapeutic implication of these observations is that MAPK inhibitors will be most beneficial as a therapeutic agent in p53 normal colon cancers where constitutively active MAPK resulting from a Ras mutation is required for cell survival. 15325273

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE Microsatellite instability (MSI), TP53 mutation, and KRAS mutation status have been reported as prognostic factors in colon cancer. 16110022

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE This was confirmed by logistic regression, as the GSTT1 null polymorphism in combination with either the TP53 or the CASP8 polymorphism significantly alter colon cancer risk (p(interaction) < 0.02 for both). 16217767

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker BEFREE Here, we examined the roles of p53 and p21(Cip1/WAF1) in senescence development induced by CKII inhibition using wild-type, isogenic p53-/- and isogenic p21-/- HCT116 human colon cancer cell lines. 19855935

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE Simple staining for beta-galactosidase allowed us to confirm that the colon cancer cell lines LIM1215 and HCT116, as well as the breast cancer cell line MCF7. have wild-type p53, and the colon cancer cell line Caco-2 as well as breast cancer cell lines MDA-MB-435 and MDA-MB-231 have mutant p53. 12725531

2003

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE Mechanistic studies were performed in two each of p53 wild-type (HCT116, LoVo) and p53-mutated (SW480, HT29) colon cancer cells to explore whether LKB1 loss could be deregulated by NKX2-1-mediated p53 pathway. 24879590

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 GeneticVariation BEFREE The influence of two allelic polymorphisms of GSTM1 and GSTT1, and that of p53 gene codon 72 on colon cancer was investigated. 18630481

2008