Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 AlteredExpression BEFREE Studies on the p53 expression and outcome for women with ovarian carcinoma have produced conflicting results. 20629008

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE These data confirm the findings of previous investigations describing TP53 mutation in ovarian carcinoma and demonstrate that archival paraffin-embedded tissues can be used for such analyses. 9301456

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Identical p53 mutations were detected in the primary ovarian carcinoma and the subsequent MMMT in each case. 12068173

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE We conclude that mutation and allelic loss of p53 are common and probably related events in the development of ovarian carcinoma. 7909153

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Our NGS study of BM of ovarian carcinoma revealed a significant number of BRCA-mutations beside TP53, ATM and CHEK2 mutations. 28497333

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Determining p53 mutational status can be useful in predicting therapeutic response to drugs effective in ovarian carcinoma. 11099323

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Recently, this category of ovarian carcinoma has gained increasing attention owing to the recognition of morphological varieties of TP53-mutated high-grade ovarian carcinoma. 30636633

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE In conclusion, the present results are consistent with a role of p53 as a determinant of chemosensitivity of ovarian carcinoma. 8630996

1996

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma. 26847329

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE We demonstrated that in a unique population of HGSOC cancer cells with cancer stem cell properties, p53 protein aggregation is associated with p53 inactivation and platinum resistance. 25263447

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Mutant p53 is frequently detected in endometrial and ovarian carcinoma, but it is rare in cervical cancers. 9546366

1998

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Thus, considering the susceptibility to spontaneous mutations of the p53 gene in advanced ovarian carcinoma, the selection process resulting in emergence of p53 mutant tumors is a possible origin of resistance of ovarian carcinoma to DNA-damaging agents. 10437915

1999

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Alteration of p53 gene in ovarian carcinoma: clinicopathological correlation and prognostic significance. 7981076

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE In this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3). 19676105

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis. 21552211

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Our findings indicate that the adverse prognosis associated with TP53 and PIK3CA mutations in human cancers can be functionally replicated in mouse models of type I→type II OvCA progression. 23499052

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Prospective study of the efficacy and utility of TP53 mutations in circulating tumor DNA as a non-invasive biomarker of treatment response monitoring in patients with high-grade serous ovarian carcinoma. 30887755

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE The objective of this study is to investigate whether wild-type TP53 status in high-grade serous ovarian carcinoma is associated with poorer survival. 23800698

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE The clinicopathological features of high-grade serous ovarian carcinoma (HGS-OvCa) patients with GOF p53 mutations were evaluated according to a comprehensive somatic mutation profile comprised of whole exome sequencing, mRNA expression, and protein expression profiles obtained from the Cancer Genome Atlas (TCGA). 23967324

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Growth suppression of human ovarian carcinoma OV-MZ-2a and OV-MZ-32 cells mediated by gene transfer of wild-type p53 enhanced by chemotherapy in vitro. 10741907

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 AlteredExpression BEFREE p53 inhibitor can increase the growth rate of subcutaneously transplanted tumor in nude mice. p53 inhibitor could decrease the expression of p53 and p21 at both mRNA and protein levels and increase the expression of MDM2 at both mRNA and protein levels in ovarian carcinoma transplanted subcutaneously in nude mice. 29565482

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Since the p53 gene has been identified as a determinant of response to chemotherapy in ovarian carcinoma in previous studies, we investigated the significance of the p53 status in response to topotecan as second-line therapy. 16127286

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE These findings demonstrate the potential of the p53 tumor suppressor gene therapy in human ovarian carcinoma. 8622881

1996

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE 96 of the ovarian carcinoma cases had been previously examined for mutations in TP53 and/or for overexpression of the TP53 protein. 9038623

1996

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE An abundance of p53 null mutations in ovarian carcinoma. 8700537

1996