×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
Biomarker
HPO
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
CausalMutation
CGI
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Germ line DNA isolated from peripheral leukocytes of 73 patients with ovarian carcinoma was screened for p53 sequence abnormalities utilizing single-strand conformation polymorphism analysis and direct PCR sequencing techniques.
7672703
1995
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
We conclude that mutation and allelic loss of p53 are common and probably related events in the development of ovarian carcinoma .
7909153
1994
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Alteration of p53 gene in ovarian carcinoma : clinicopathological correlation and prognostic significance.
7981076
1994
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Mutations at the p53 tumor suppressor gene locus are a frequent genetic alteration associated with human ovarian carcinoma .
8005584
1994
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
AlteredExpression
BEFREE
The prognostic significance of Bcl-2 and p53 expression in ovarian carcinoma .
8616869
1996
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
These findings demonstrate the potential of the p53 tumor suppressor gene therapy in human ovarian carcinoma .
8622881
1996
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
Biomarker
BEFREE
In conclusion, the present results are consistent with a role of p53 as a determinant of chemosensitivity of ovarian carcinoma .
8630996
1996
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
An abundance of p53 null mutations in ovarian carcinoma .
8700537
1996
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
96 of the ovarian carcinoma cases had been previously examined for mutations in TP53 and/or for overexpression of the TP53 protein.
9038623
1996
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
These data confirm the findings of previous investigations describing TP53 mutation in ovarian carcinoma and demonstrate that archival paraffin-embedded tissues can be used for such analyses.
9301456
1997
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Mutant p53 is frequently detected in endometrial and ovarian carcinoma , but it is rare in cervical cancers.
9546366
1998
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Thus, considering the susceptibility to spontaneous mutations of the p53 gene in advanced ovarian carcinoma , the selection process resulting in emergence of p53 mutant tumors is a possible origin of resistance of ovarian carcinoma to DNA-damaging agents.
10437915
1999
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Growth suppression of human ovarian carcinoma OV-MZ-2a and OV-MZ-32 cells mediated by gene transfer of wild-type p53 enhanced by chemotherapy in vitro.
10741907
2000
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53 .
10880552
2000
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
Biomarker
BEFREE
The prognostic significance and nature of p53 dysfunction in ovarian carcinoma is unclear.
11064359
2000
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Determining p53 mutational status can be useful in predicting therapeutic response to drugs effective in ovarian carcinoma .
11099323
2000
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
The aim of the study was to evaluate the relationship between p53 protein accumulation, p53 gene mutation and response to cisplatin-based chemotherapy in patients with ovarian carcinoma considering conventional clinicopathological parameters.
11125280
2001
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
The aim of this study is to determine the status of p53 gene alteration in this distinct type of ovarian carcinoma .
11161858
2001
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Identical p53 mutations were detected in the primary ovarian carcinoma and the subsequent MMMT in each case.
12068173
2002
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Although these pooled estimates might appear to offer support for various hypotheses regarding the role of p53 in ovarian carcinoma , the limitations inherent in these data hamper the interpretation of the significance of any of the findings.
12518363
2003
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
AlteredExpression
BEFREE
We retrospectively examined the overexpression of p53 in primary ovarian carcinoma , and its association with chemotherapeutic efficacy.
12668287
2003
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
AlteredExpression
BEFREE
Inactivation of p53 is detected in 30-40% of ovarian carcinoma .
12770737
2003
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Influence of p53 status on the HSV-Tk/GCV-induced bystander effect in a panel of human ovarian carcinoma cell lines.
16050136
2005