Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate each subtype's response to chemotherapy. 30188916

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE We have recently observed that microRNA-31 (miR-31) expression is associated with BRAF mutation and prognosis in CRC. 25232271

2014

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE No significant correlations between KRAS and BRAF mutations and various clinicopathological parameters was found.This is the first report of KRAS and BRAF status in Albanian patients with colorectal carcinoma (CRC) and though the relatively small sample size might not provide enough statistics power. 25267307

2014

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE The BRAF mutation was frequently seen in SSA and in sporadic MSI-H CRC, both of which were associated with DNA methylation. 15247181

2004

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Mutant KRAS and BRAF are associated with primary EGFR inhibitor resistance in colorectal cancer (CRC). 30106444

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Presence of mutated BRAF is one of the most powerful prognostic factors for advanced and recurrent CRC. 21285991

2011

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE In this prospective study of older women, cigarette smoking was associated with the MSI-high, CIMP-positive, and BRAF mutation-positive colorectal cancer subtypes, which indicates that epigenetic modification may be functionally involved in smoking-related colorectal carcinogenesis. 20587792

2010

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE DNA extraction was attempted on 11 search-retrieved paired cases of histological resections or excisions of CRC and their corresponding cytological samples (representing metastases) and tested for KRAS mutations in exon 2 and 3, as well as BRAF exon 15 mutations by Sanger sequencing. 21029218

2011

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE We performed IHC for BRAF V600E (VE1) on 204 cases of colorectal carcinoma including 59 with the BRAF V600E mutation. 24921639

2014

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE There were also tendencies toward associations of Fn-high with the BRAF V600E mutation (P = 0.047) and active Crohn-like lymphoid reactions (P = 0.052) in MSI-H CRCs. 28597080

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE We evaluated 14 cases of colorectal cancer with MSI that were BRAF wild type but demonstrated a KRAS mutation. 26523369

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 AlteredExpression BEFREE In each cell line, Kras knockdown was mirrored by down-regulation of Cten Since Kras signals through Braf, we tested the effect of Kras knockdown in CRC cell line Colo205 (which shows high Cten expression and is mutant for BRAF but wild type for KRAS). 21698197

2011

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE KRAS and BRAF are mutated in 35% and 10% of colorectal cancers, respectively. 19913317

2010

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Molecular analysis of sporadic CRCs in Group 2 showed that diffuse TOPK expression was associated with KRAS and BRAF mutations (p<0.001) and with poor outcome in patients with either mutation in univariate and multivariate analysis (P=0.017). 19935791

2010

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Emerging new approaches have revealed gradual changes in BRAF mutation and CIMP-high throughout the colorectum in CRCs. 24752710

2014

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Advances on the BRAF Front in Colorectal Cancer. 29610287

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR. 31711486

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Together, these results highlight BRAF as a potential target for therapeutic intervention in sporadic MSI-H colorectal cancers. 17427169

2007

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Activating mutations of the KRAS, BRAF or PIK3CA oncogenes are frequently found in colorectal cancer. 21424126

2011

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE We investigated the associations between v-Raf murine sarcoma viral oncogene homolog B1 (<i>BRAF</i><sup>V600E</sup>, henceforth <i>BRAF</i>) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog <i>(</i><i>KRAS</i>) mutations and colorectal cancer (CRC) prognosis, using The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GSE39582) datasets. 30658510

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE The SIM-AIMS assay could also detect WT and V600E BRAF in CRC specimens, but the measured levels of both targets were lower than those determined by MRM assay. 27497007

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Quantitative Detection and Resolution of BRAF V600 Status in Colorectal Cancer Using Droplet Digital PCR and a Novel Wild-Type Negative Assay. 26762843

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Real-time polymerase chain reaction identifies the most common BRAF mutation, V600E, in frozen or paraffin-embedded colorectal cancer tissue. 20670148

2010

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Current guidelines on resection margins are adequate for BRAF mutation-positive colorectal cancers. 28210747

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Sporadic colorectal cancers with a high degree of microsatellite instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are widely considered to develop from serrated polyps. 17101316

2006