Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE <b/> BRAF mutations in colorectal cancer portend a poor prognosis, with first-line treatment often involving triplet or quadruplet chemotherapy, and single-agent targeted therapy with BRAF inhibitors failing to demonstrate clinical activity. 28576843

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE 2- Interestingly, serpinE2 mRNA and protein were also markedly enhanced in human CRC cells exhibiting mutation in KRAS and BRAF. 20942929

2011

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE 3'-Deoxy-3'-18F-fluorothymidine PET predicts response to (V600E)BRAF-targeted therapy in preclinical models of colorectal cancer. 23341544

2013

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. 15542810

2004

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. 18806830

2009

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Colorectal cancer (CRC) mortality was not associated with the traditional, alternate, or serrated pathways, but was associated with a subset of pathway-unassigned tumors (MSS or MSI low, CIMP negative, BRAF mutation negative, and KRAS mutation positive) (n = 96 cases; relative risk = 1.76; 95% confidence interval, 1.07-2.89, compared with the traditional pathway). 23665275

2013

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. 14734469

2004

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors. 16015629

2005

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer. 16381005

2006

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status. 16403224

2006

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. 18098337

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF-activating mutations have been reported in several types of cancer, including melanoma ( approximately 70% of cases), thyroid (30-70%), ovarian (15-30%), and colorectal cancer (5-20%). 18458053

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival. 18602919

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients. 18778891

2009

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF V600E is the predominantly occurring mutation of the cytoplasmic kinase BRAF, and, in colorectal cancer, its determination provides a diagnostic exclusion criterion for hereditary nonpolyposis colorectal cancer. 19213871

2009

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutation testing in colorectal cancer. 20670148

2010

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutations are specific for serrated adenocarcinoma and identify a subset of serrated adenocarcinomas with gene methylation and a tendency for MSI-H. A high frequency of KRAS mutations in serrated adenocarcinomas suggests that a significant proportion of KRAS-mutated CRCs originate from serrated precursors, thus challenging the traditional model of Vogelstein. 21457162

2011

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutations in colorectal cancer are associated with distinct clinical characteristics and worse prognosis. 22228154

2012

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF V600E mutations were not identified in the early-onset colorectal carcinoma group. 22481281

2012

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics. 22899730

2012

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutations in melanoma and colorectal cancer: a single oncogenic mutation with different tumour phenotypes and clinical implications. 23246082

2013

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF and codon 12 KRAS mutations predict for adverse outcome of CRC patients receiving cetuximab. 23374602

2013

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF V600E-specific immunohistochemistry for the exclusion of Lynch syndrome in MSI-H colorectal cancer. 23553055

2013

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF mutation is seen in melanoma, papillary thyroid carcinoma (including papillary thyroid carcinoma arising from ovarian teratoma), ovarian serous tumours, colorectal carcinoma, gliomas, hepatobiliary carcinomas and hairy cell leukaemia. 23594689

2013

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE BRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma. 23650027

2013