Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE The ability to counteract PPARgamma suggests that gammaORF4 plays a role in the pathogenesis of colorectal cancers. 15857827

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE These findings suggest that PPARgamma gene polymorphism may be implicated with the development of colorectal cancers, in which K-ras gene is not mutated. 11956653

2002

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE Each colorectal carcinoma cell line expressed PPARgamma. 12711249

2003

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism. 16489531

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE The purpose of this study was to evaluate whether EP(1-4) subtype, PPAR gamma receptor and COX-1/COX-2 expression in colorectal cancer are related to tumor-specific mortality. 17290397

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE On the contrary, two other SNPs, PLA2G2A c.435+230C>T and PPARG c.1431C>T (p.His477His), were associated with a decrease in CRC risk. 18992148

2008

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese. 16965392

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE These findings suggest that the relationship between UHRF1 and PPARG may have a relevant role in CRC progression. 22286757

2012

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE This is the first report that IL6, IL8, and PPARG genes are important in relation to inflammation-related risk of sporadic CRC. 12839942

2003

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE In summary, we identified a panel of proteins correlated with PPARγ expression that could be associated with CRC unveiling new pathways to be investigated for the selection of novel potential prognostic/predictive biomarkers and/or therapeutic targets. 27499265

2016

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk. 30489355

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE This meta-analysis suggests that the Ala allele of the PPARgamma P12A polymorphism might be a protective factor for colorectal cancer, but a risk factor for gastric cancer. 20596649

2010

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE PPARgamma agonists have been shown to reduce the growth of colorectal carcinoma cells in culture and in xenograft models. 17390024

2007

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Here, we found that 15-hydroxy-eicosatetraenoic acid (15S-HETE), an endogenous ligand for PPARgamma, was significantly decreased in the serum of patients with colorectal cancer. 14566836

2003

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE In conclusion, SOX9, β-catenin and PPARγ expression levels are deregulated in the CRC tissue, and in colon cancer cell lines ligand-dependent PPARγ activation unevenly influences SOX9 and β-catenin expression and subcellular localization, suggesting a variable mechanistic role in colon carcinogenesis. 23583560

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Ensemble of gene signatures identifies novel biomarkers in colorectal cancer activated through PPARγ and TNFα signaling. 24133572

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE The current meta-analysis has established that ADH1B (rs1229984) and PPARG (rs1801282) are two risk variants of CRC. 24552298

2014

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE Thus, codeficiency of Cav1 and adenomatous polyposis coli facilitated formation of CRC, and activation of PPARg may offer novel strategies for treatment of CRC. 23640045

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE This study shows that PPARgamma agonists up-regulate KLF4 expression in receptor-dependent manner, and KLF4 was identified as a novel transcription factor that controls NAG-1 promoter activity in human and mouse colorectal cancers. 20385121

2010

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 GeneticVariation BEFREE Our results provide new evidence of association between PPARG variants and colorectal cancer risk. 24045924

2013

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 AlteredExpression BEFREE RT-PCR and Western blot analysis showed that both human CRC cell lines expressed PPARgamma mRNA and protein. 16520894

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE The combination of resveratrol with a PPARγ agonist could be a promising pharmacological approach for treatment of colorectal cancer. 24975132

2014

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Interactions of peroxisome proliferator-activated receptor {gamma} and diet in etiology of colorectal cancer. 15894676

2005

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARγ/OCTN2 pathway. 25075794

2014

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.500 Biomarker BEFREE Peroxisome proliferator-activated receptor gamma (PPAR(gamma)) ligands inhibit cell growth of colorectal cancer cells in most experimental models, but no significant effect could be observed in patients with colorectal cancer. 15911106

2005